Takashi Nakakuki

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Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG) determines distinct cell-fate decisions, although signals propagate through shared pathways. Using mathematical modeling and experimental approaches, we unravel how HRG and EGF generate distinct, all-or-none responses of the phosphorylated transcription factor c-Fos. In the(More)
Ligand-induced homo- and hetero-dimer formation of ErbB receptors results in different biological outcomes irrespective of recruitment and activation of similar effector proteins. Earlier experimental research indicated that cells expressing both EGFR (epidermal growth factor receptor) and the ErbB4 receptor (E1/4 cells) induced E1/4 cell-specific B-Raf(More)
BACKGROUND Epidermal growth factor receptor (EGFR) signaling plays an important role in the regulation of cell proliferation, survival, metastasis, and invasion in various tumors. Earlier studies showed that the EGFR is frequently overexpressed in non-small-cell lung cancer (NSCLC) and EGFR mutations at specific amino acid residues in the kinase domain(More)
Mutation and/or dysfunction of signaling proteins in the mitogen activated protein kinase (MAPK) signal transduction pathway are frequently observed in various kinds of human cancer. Consistent with this fact, in the present study, we experimentally observe that the epidermal growth factor (EGF) induced activation profile of MAP kinase signaling is not(More)
— In this paper, we consider how to realize a PID controller and a signal transmission system in a biochemical reaction network, which are fundamental issues in a design of molecular robot. Since a negative feedback is implemented with an inhibition reaction in an intracellular signal transduction system instead of a negative gain or an error signal, some(More)
The paper presents an adaptive controller design for a class of nonsmooth systems with uncertainty. The design method is based on the concept of the Filippov solution since a classical approach can not be applied to establish the stability of the adaptive control system. It is shown by means of a solid nonsmooth analysis that the adaptive control system is(More)
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