Takashi Nagaya

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VEGF (vascular endothelial growth factor) secreted from tumor cells including breast cancer serves as a potent angiogenic factor which favors tumor growth and metastasis. Indeed, a higher concentration of serum VEGF has been shown to associate with a poorer prognosis in patients with breast cancer. On the other hand, constitutive expression of a(More)
Interleukin (IL)-8 produced from glioblastoma is suggested to contribute to its own proliferation and progression. Since various external stimuli have been shown to increase intracellular Ca(2+) in glioma cells, we investigated Ca(2+) mobilization-dependent IL-8 expression and effect of cyclosporin A (CsA), an inhibitor of calcineurin (Cn), on the(More)
Thyroid hormone is one of the critical hormones in mammals and plays an indispensable role in development as well as in lipid and carbohydrate metabolism and energy generation. The thyroid gland secretes mainly L-thyroxine (T4) into the circulation where it is converted to 3,5,3′-triiodothyronine (T3) in liver and kidney. Most of the serum T3 is derived(More)
A recent western study reports that t(2; 3)(q13; p25) translocation resulting in the expression of the Pax8-PPAR gamma fusion gene in patients with thyroid follicular carcinoma (FTC) occurs with high incidence (63%). Furthermore, the products of the fusion gene were shown to suppress the function of PPAR gamma in a predominantly negative manner, conferring(More)
Peroxisome proliferator-activated receptor gamma (PPARgamma) belongs to a superfamily of thyroid / steroid hormone receptors and regulates transcription of their target genes in a ligand-dependent manner. Recently, PPARgamma was reported to be expressed in several cell lines derived from breast, colon, stomach and lung cancers. Activation of PPARgamma by(More)
Calpain is a Ca(2+)-activated neutral protease that supposedly plays a key role in myocardial dysfunction following ischemia/reperfusion, by degrading certain proteins involved in the contraction mechanism. It is possible that overexpression of calpastatin, an endogenous calpain inhibitor, lessens contractile dysfunction in the heart after reperfusion by(More)
The evaluation strategy (abbr. the E-strategy) initiated by OBJ2 is one of compromises between outermost and innermost reduction strategies. Although rewriting with the E-strategy is intuitively easy-to-understand, the straightforward implementation cannot lead to e cient rewriting. Then, the implementations of OBJ3 and CafeOBJ use evaluated ags to(More)
BACKGROUND A dextran sulfate column (Liposorber) has been developed and proven effective in LDL apheresis for removing LDL from patients with hyperlipemia. Chronic renal failure (CRF) patients with arteriosclerosis obliterans (ASO) treated with Liposorber have been shown good results. METHODS We analyzed proteins absorbed by Liposorber in CRF patients(More)