Takashi Kubo

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OBJECTIVES The aim of the present study was to evaluate the ability of optical coherence tomography (OCT) for assessment of the culprit lesion morphology in acute myocardial infarction (AMI) in comparison with intravascular ultrasound (IVUS) and coronary angioscopy (CAS). BACKGROUND Optical coherence tomography is a new intravascular imaging method with a(More)
OBJECTIVES The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with(More)
Faculty of Engineering Yokohama National University, 79–5 Tokiwadai, Hodogaya-ku, Yokohama 240–8501, Japan, Graduate School of Environment and Information Sciences, Yokohama National University, 79–7 Tokiwadai, Hodogaya-ku, Yokohama 240–8501, Japan, and Graduate School of Pharmaceutical Sciences, Kyushu University, 3–1–1 Maidashi, Higashiku, Fukuoka(More)
OBJECTIVES We used virtual histology intravascular ultrasound (VH-IVUS) to investigate the natural history of coronary artery lesion morphology. BACKGROUND Plaque stability is related to its histological composition. METHODS We performed serial (baseline and 12-month follow-up) VH-IVUS studies and examined 216 nonculprit lesions (plaque burden >or=40%)(More)
OBJECTIVES The aim of the present study was to compare lesion morphologies after sirolimus-eluting stent (SES) implantation between patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) with the use of optical coherence tomography (OCT). BACKGROUND The lesion morphologies before and after coronary stenting have been proposed as(More)
We sought to examine the intravascular ultrasound (IVUS) findings of stent fracture. Stent fracture has been implicated as a cause of drug-eluting stent failure. IVUS is more likely to identify mechanisms of stent failure -- including stent fracture -- than angiography. Twenty stent fractures diagnosed by IVUS in 17 patients were evaluated. Eighteen stent(More)
Cytochrome P450 (CYP) 2D6 is an important drug-metabolizing enzyme, and its gene is known to be highly polymorphic. Here, we report five novel nonsynonymous single nucleotide polymorphisms (SNPs), and 65 other sequence variations detected from the gene coding for cytochrome P450 (CYP) 2D6 in 254 Japanese subjects. Two of the novel nonsynonymous SNPs were(More)
BACKGROUND For the identification of functionally significant coronary artery disease, there have not been any dedicated optical coherence tomography (OCT) studies reported previously, although OCT can clearly detect coronary vessel lumina at higher resolution than intravascular ultrasound (IVUS). METHODS AND RESULTS OCT and fractional flow reserve (FFR)(More)
Autopsy studies have suggested that acute myocardial infarction (AMI) represents a pan-coronary process of vulnerable plaque development. We performed multifocal optical coherence tomographic (OCT) examination to compare coronary lesion instability between AMI and stable angina pectoris (SAP). A total of 42 patients with AMI (n = 26) or SAP (n = 16) who had(More)
OBJECTIVES The purpose of this study was to investigate whether multidetector computed tomography (MDCT) can noninvasively help assess thin-cap fibroatheroma (TCFA). BACKGROUND Plaque rupture and thrombus formation play key roles in the onset of acute coronary syndrome. TCFA is recognized as a precursor lesion for plaque rupture, and MDCT angiography can(More)