Takashi Kitanaka

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Hiroshi Kobayashi18
A Hidaka18
Toshiyuki Sado15
Shoji Haruta14
Shozo Yoshida13
20Hiroshi Kobayashi
18A Hidaka
16Toshiyuki Sado
14Shoji Haruta
13Shozo Yoshida

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1970
2011
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A randomized study of screening for ovarian cancer: a multicenter study in Japan.
Ovarian cancer is common in women from developed countries. We designed a prospective randomized controlled trial of ovarian cancer screening to establish an improved strategy for the early detection of cancers. Asymptomatic postmenopausal women were randomly assigned between 1985 and 1999 to either an intervention group (n = 41,688) or a control group (n =… (More)
Fetal responses to long-term hypoxemia in sheep.
The effect of acute or short-term hypoxia on fetal cardiovascular hemodynamics has been well known; however, little is known about the effect of long-term hypoxemia. To determine the fetal hemodynamic responses to this stress we studied two groups of animals: 1) pregnant ewes (n = 20) at 110-115 days of gestation subjected to hypoxia for up to 28 days and… (More)
Maternal responses to long-term hypoxemia in sheep.
To determine the maternal cardiovascular responses to long-term hypoxemia, we studied three groups of animals: 1) pregnant ewes (n = 20) at 110-115 days gestation subjected to hypoxia for up to 28 days; 2) pregnant ewes (n = 4) that served as normoxic controls; and 3) nonpregnant ewes (n = 6) subjected to hypoxemia for up to 28 days. We measured mean… (More)
Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor.
The detection of an ovarian mass during pregnancy is often a diagnostic challenge. We describe 2 cases of ovarian endometrioma during pregnancy with marked mural nodules on the cyst wall. The sonographic and MR imaging findings mimicked ovarian cancer. Surgical intervention may still be inevitable to exclude the possibility of malignancy.
Ovarian endometrioma--risks factors of ovarian cancer development.
OBJECTIVE Our prospective studies in Japan have found an increased ovarian cancer incidence in women with ovarian endometrioma (standardized incidence ratio, 8.95; 95% confidence intervals, 4.12-5.3). The risk increased with increasing age at ovarian endometrioma diagnosis. The goal of this study was to define the risk factor(s) of ovarian cancer… (More)
Prevalence of ovarian cancer among women with a CA125 level of 35 U/ml or less.
BACKGROUND The optimal upper limit of the normal range for CA125 in ovarian cancer screening is unknown. We investigated the prevalence of ovarian cancer among women in the Shizuoka Cohort Study on Ovarian Cancer Screening (SCSOCS) trial who had an abnormal ultrasound (US) and a CA125 level of 35 U/ml or less. METHODS Of 48,027 women enrolled in the… (More)
Anticytokine therapy in preterm labor: current knowledge and future perspectives.
AIMS Up to 10% of pregnant women have preterm birth that might be refractory to current therapy. Infections and asphyxia related to preterm birth are the causes of death in the majority of neonates and therefore represent an urgent clinical need. METHODS The present article reviews the English language literature for preclinical and clinical trials and… (More)
Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia.
PROBLEM Preeclampsia, a pregnancy-specific hypertensive syndrome, is one of the leading causes of premature births as well as fetal and maternal death. Preeclampsia lacks effective therapies because of the poor understanding of disease pathogenesis. The aim of this paper is to review molecular signaling pathways that could be responsible for the… (More)
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis.
The purpose of this study was to determine whether Akt and mammalian target of rapamycin (mTOR), downstream targets of phosphatidylinositol 3-kinase, are activated in endometriosis and ovarian cancer specimens. We measured total and phosphorylated levels of Akt and mTOR from 17 frozen ovarian cancers and 15 benign endometriosis specimens (nine from… (More)
First trimester biological markers for the prediction of pregnancy-induced hypertension.
The purpose of this study is to predict pregnancy-induced hypertension (PIH) by standard methods at the first antenatal visit prior to the 12th gestational week (GW). This is a retrospective study of 1189 primipara and 957 multipara who delivered singleton babies having no major malformations after the 32nd GW. Multiple regression analysis for the… (More)