Takashi Kagaya

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The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To understand the mechanisms by which UC patients develop colon carcinomas, we used a mouse model of the disease whereby administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion causes severe colonic inflammation and the(More)
We compared the abundance of litter categories (coarse particulate organic matter 1–16 mm, leaves >16 mm, and small woody detritus 16–100 mm) and macroinvertebrate assemblages between natural litter patches in pools and riffles in a headwater stream. Litter patches in pools were formed under conditions of almost no current (<6 cm s−1), but in riffles they(More)
Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1. We first constructed octn1 gene knockout (octn1 −/− ) mice. Metabolome analysis was then performed to identify substrates in vivo. The possible association(More)
We determined the flight capabilities and feeding habits of adults of nine silphine beetle species and illustrated their relationship. We examined the silphine beetles for the presence or absence of flight muscles and estimated their feeding habits by comparing the carbon and nitrogen stable isotope ratios for them with those of necrophagous nicrophorine(More)
UNLABELLED Radiofrequency ablation (RFA) is one of the treatments for hepatocellular carcinoma (HCC) and is known to enhance host immune response. However, the epitopes to which enhanced immune responses occur, the impact on patient prognosis, and the functions and phenotype of T cells induced are still unclear. To address these issues, we analyzed immune(More)
BACKGROUND The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, largely as a result of intrahepatic metastasis. Using a mouse model of intrahepatic metastasis, we investigated whether chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) could potentiate the antitumor effects of the herpes simplex virus thymidine(More)
Flightlessness in insects is generally thought to have evolved due to changes in habitat environment or habitat isolation. Loss of flight may have changed reproductive traits in insects, but very few attempts have been made to assess evolutionary relationships between flight and reproductive traits in a group of related species. We elucidated the(More)
Different types of litter patches with contrasting macroinvertebrate assemblages have been observed within a stream reach. This study examined whether distributions of macroinvertebrates among three litter patch types (riffle, middle, edge) were consistent between reaches with different channel characteristics in headwater streams in central Japan. Mass of(More)
Wood-rotting fungi are major organisms exploiting coarse woody debris (CWD) in forests. Here, guild structure of wood-rotting fungi was investigated in cool temperate (Chichibu) and warm temperate (Chiba) forests in central Japan, based on their occurrence on CWD of different volumes and decay stages. Analysis with the program partitioning around medoids(More)
UNLABELLED Many tumor-associated antigens (TAAs) recognized by cytotoxic T cells (CTLs) have been identified during the last two decades and some of them have been used in clinical trials. However, there are very few in the field of immunotherapy for hepatocellular carcinoma (HCC) because there have not been comparative data regarding CTL responses to(More)