Takashi Horikawa

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In vivo effects of single and repeated interferon-alpha administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Single interferon-alpha administration (15, 30 and 60 X 10(6) U/kg i.p.) had no significant effect on the levels of monoamines and their metabolites or monoamine turnover. When(More)
We have investigated the response of adenylate cyclase to GTP and to dopamine (DA) in striatal membranes of rats treated for 3 weeks with chlorpromazine or haloperidol, and further measured the level of Gi (an inhibitory GTP-binding protein) or Go (a similar GTP-binding protein of unknown function) in 3 areas (cerebral cortex, striatum and hippocampus)(More)
The fact that multi-core CPUs have become so common and that the number of CPU cores in one chip has continued to rise means that a server machine can easily contain an extremely high number of CPU cores. The CPU scalability of IT systems is thus attracting a considerable amount of research attention. Some systems, such as ACID-compliant DBMSs, are said to(More)
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the alpha7 nicotinic acetylcholine (alpha7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the alpha7 receptor.
ACID-compliant DBMSs are said to be difficult to scale their performance by using many more processors, which means that they are difficult to enjoy the benefits of recent many-core systems that widespread use of multi-core processors has made practicable. Since DBMSs are indispensable in most of IT systems, scalability issues should be addressed to fulfill(More)
Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. The present study was undertaken to clarify the beneficial effects of MP-124, a novel PARP-1 inhibitor, on neurological deficits and cerebral infarcts following(More)
The response of adenylate cyclase to GTP and to dopamine (DA) was investigated in striatal membranes from desipramine (DMI)- or saline-treated rats. DMI (15 mg/kg) or saline was injected i.p. once a day for 3 weeks. In saline-treated control membranes, GTP exerted a biphasic effect on basal and DA-stimulated enzyme activity; peak levels of stimulation by DA(More)
ACID-compliant DBMSs are said to be difficult to scale their performance by using many more processors, which means that they are difficult to enjoy the benefits of recent manycore systems that wide-spread use of multi-core processors has made practicable. Since DBMSs are indispensable in most of IT systems, scalability issues should be addressed to fulfill(More)
Many-core systems differ from traditional multi-processor systems in performance characteristics and sometimes behave in unfamiliar ways for us. This can lead us facing performance troubles from unknown causes, requiring long time to fix them. To address those situations it is important for us to accumulate technology and know-how on performance of(More)