Takashi Horikawa

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The fact that multi-core CPUs have become so common and that the number of CPU cores in one chip has continued to rise means that a server machine can easily contain an extremely high number of CPU cores. The CPU scalability of IT systems is thus attracting a considerable amount of research attention. Some systems, such as ACID-compliant DBMSs, are said to(More)
ACID-compliant DBMSs are said to be difficult to scale their performance by using many more processors, which means that they are difficult to enjoy the benefits of recent many-core systems that widespread use of multi-core processors has made practicable. Since DBMSs are indispensable in most of IT systems, scalability issues should be addressed to fulfill(More)
OBJECTIVE The goal of this study was to identify a reliable biomarker for age-related infertility. DESIGN Laboratory study. SETTING ART laboratory. PATIENT(S) Patients undergoing intracytoplasmic sperm injection or IVF cycles. INTERVENTION(S) Expression of Glutathione S-transferase (GST) mRNA and protein in mural and cumulus granulosa cells obtained(More)
AIM To investigate whether laparoscopic proximal tubal division for the treatment of hydrosalpinges could preserve ovarian function. METHODS From June 2002 to October 2006, before assisted reproductive treatment (ART), a total of 17 infertile patients with bilateral hydrosalpinges were studied--11 patients underwent laparoscopic proximal tubal division(More)
Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. The present study was undertaken to clarify the beneficial effects of MP-124, a novel PARP-1 inhibitor, on neurological deficits and cerebral infarcts following(More)
Puerose: To demonstrate our hypothesis that a correlation exists between oocyte maturity and a decrease in intraovarian blood flow resistance in assisted reproductive technology (ART) treatment cycles, oocyte maturity and total antioxidant status (TAOS) in follicular fluid was examined. Methods: A total of 59 cycles involving 51 infertile patients(More)
To evaluate the cystectomy-induced damage on the follicular growth and ovulation of an affected ovary during natural cycles. Twenty-eight infertile patients with unilateral ovarian endometriomas who underwent laparoscopic cystectomy were retrospectively evaluated. The ovulation rate of an affected ovary during natural cycles was compared before and after(More)
AIM To clarify the effect of laparoscopic cystectomy for ovarian endometrioma in infertility patients, the pregnancy outcome was evaluated. METHODS This was a retrospective study. From August 2002 to February 2006, 33 infertility patients with ovarian endometrioma underwent laparoscopic cystectomy at our center. According to the laparoscopic findings 33(More)
To establish an index to predict ART outcomes and to identify infertile patients who need LH supplementation during ovarian stimulation. Serum LH concentrations were measured during the mid- and late-follicular phase in 86 normogonadotropic infertile patients who underwent ART treatment using GnRH-agonist long protocol with recombinant-FSH. The(More)
Recent studies have suggested that the alpha7 nicotinic acetylcholine receptors play important roles in learning and memory. Herein, we describe our research of the structure-activity relationships (SAR) in a series of (S)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-ones bearing various bicyclic moieties to discover novel alpha7 receptor agonists.(More)