Takashi Fukuda

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Quality adjustment weights for quality-adjusted life years (QALYs) are available with the EQ-5D Instrument, which are based on a survey that quantified the preferences of the British public. However, the extent to which this British value set is applicable to other, especially non-European, countries is yet unclear. The objectives of this study are (a) to(More)
Although the threshold of cost effectiveness of medical interventions is thought to be 20 000- 30 000 UK pounds in the UK, and $50 000-$100 000 in the US, it is well known that these values are unjustified, due to lack of explicit scientific evidence. We measured willingness-to-pay (WTP) for one additional quality-adjusted life-year gained to determine the(More)
Accurate voice activity detection (VAD) is important for robust automatic speech recognition (ASR) systems. This paper proposes a statistical-model-based noise-robust VAD algorithm using long-term temporal information and harmonic-structure-based features in speech. Long-term temporal information has recently become an ASR focus, but has not yet been deeply(More)
A case of primary Hodgkin's disease, a lymphocyte-predominant entity, occurring in the stomach is described. The patient was a 37-year-old man who complained of general fatigue. Endoscopic biopsy revealed gastric malignant lymphoma. Subtotal gastrectomy and postoperative chemotherapy following a modifid CHOP regimen were performed. The patient has been free(More)
BACKGROUND In economic evaluation, cost per quality-adjusted life year (QALY) is generally used as an indicator for cost-effectiveness. Although JPY 5 million to 6 million (USD 60, 000 to 75,000) per QALY is frequently referred to as a threshold in Japan, do all QALYs have the same monetary value? METHODS To examine the relationship between severity of(More)
The purpose of this study was to measure the population norms for the Japanese versions of preference-based measures (EQ-5D-3L, EQ-5D-5L, and SF-6D). We also considered the relations between QOL score in the general population and socio-demographic factors. A total of 1143 adult respondents (aged ≥ 20 years) were randomly sampled from across Japan using(More)
OBJECTIVE To review the use of evidence in the market approval process, reimbursement, and price control mechanisms for medicines and medical devices in China, Japan, and Singapore. METHODOLOGY Documentary reviews relevant to public health policy and management by government authorities. RESULTS Drug regulatory authorities play a vital role in the(More)