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  • Daisuke Oikawa, Yukio Kimata, Kenji Kohno, Takao Iwawaki
  • Medicine, Biology
  • Experimental cell research
  • 2009 (First Publication: 1 September 2009)
  • IRE1, an ER-localized transmembrane protein, plays a central role in the unfolded protein response. Upon ER stress, IRE1 senses the accumulation of unfolded proteins in the ER, and transfers signalExpand
  • Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2009 (First Publication: 29 September 2009)
  • Inositol requiring enzyme-1 (IRE1), a protein located on the endoplasmic reticulum (ER) membrane, is highly conserved from yeast to humans. This protein is activated during ER stress and inducesExpand