Takamichi Nakamura

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The ulcer-associated cell lineage (UACL) induced at the site of ileac chronic ulceration in Crohn’s disease has been reported to show histological differentiation resembling gastric pyloric mucosa. To clarify the significance of homeobox gene-encoded transcription factors in the formation of the UACL in Crohn’s disease, we investigated the(More)
We investigated the distribution of extracellular matrix components such as fibronectin, laminin, type III, IV, V, and VI collagens and heparan sulfate proteoglycan (HSPG) in normal and diseased glomeruli using the indirect immunofluorescence method. This study included 96 renal biopsies: 7 controls, 3 minimal change nephrotic syndrome (MCNS), 47 mesangial(More)
BACKGROUND We established the reversible and the prolonged models of mesangial proliferative glomerulonephritis (GN) with anti-Thy 1 antibody 1-22-3. However, the essential factors leading to the prolonged glomerular alterations have not been identified. METHODS The expressions of several chemokines and cytokines were compared in the reversible and the(More)
The serrated polyp-neoplasia pathway is a novel concept that has been demonstrated to differ from the conventional adenoma-carcinoma pathway. To characterize the phenotypic patterns of differentiation in colorectal serrated polyps, we examined the immunohistochemical expression profile of gastric (MUC5AC, TFF1, MUC6, GlcNAcα1 → 4Gal → R, and PDX1) and(More)
Anti-tumour necrosis factor (TNF) has been shown to be pretty eVective in rheumatoid arthritis (RA), but very little is known about its eYcacy in renal impairment or on dialysis. Since RA patients with renal failure are diYcult to treat, special attentions are required to the possible increase in toxicity and to dose adjustment of the medications used to(More)
Expression of the caspase-activating adaptor ASC was reported to be associated with the production of IL-8, a primary mediator of mucosal inflammation, in vitro. However, the significance of the ASC-mediated IL-8 production in primary tissues has remained poorly understood. Primary intestinal mucosa isolated from surgically resected ileum or colon was(More)
Takamichi Nakamura, MD, The Second Department of Medicine, Yamanashi Medical School, Yamanashi 409-38 (Japan) Dear Sir, A splenic abscess is an unusual condition seen in immunocompromized patients or associated with intravenous drug abuse [1]. Several conditions including trauma, immunodeficiency, corticosteroid and/or immunosuppressive therapy and diabetes(More)
Hyperhomocysteinemia, a well-recognized cardiovascular risk factor, is frequent in hemodialysis (HD) patients. A common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C-->T substitution at nucleotide 677, is associated with homocysteine (Hcy) level elevation. We examined whether three factors involved in the methionine cycle(More)
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