Takamichi Igarashi

Learn More
Prostaglandin A1 (PGA1) increases heat shock element (HSE)-mediated transcription, thereby enhancing expression of HSE-bearing genes, including heat shock proteins. Because we recently found functional HSEs in the human and rodent c-fos promoters, we hypothesized that PGA1 might increase c-fos expression through the HSE. In this study, we revealed that PGA1(More)
Myelodysplastic syndromes (MDS) and myelodysplastic/myelopro-liferative neoplasms (MDS/MPN) are heterogeneous groups of chronic myeloid neoplasms characterized by clonal hematopoi-esis, varying degrees of cytopenia or myeloproliferative features with evidence of myelodysplasia and a propensity to acute myeloid leukemia (AML). 1 In recent years, a number of(More)
Pancreatic cancer is a common type of cancer with poor prognosis worldwide. Postoperative survival depends on the existence of metastasis. Elucidation of the mechanism underlying cancer progression is important to improve prognosis. The RAS-associated protein RAB5 activates intracellular membrane trafficking, and RAB5 expression is correlated to progression(More)
INTRODUCTION Tumours with adenocarcinoma and neuroendocrine components have often been reported, although the reason underlying the dual components remains unclear. CASE PRESENTATION A 43-year-old woman with multiple liver metastatic lesions of rectal neuroendocrine tumour underwent primary tumour resection and subsequent liver transplantation.(More)
  • 1