Takako Tominaga

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Makoto Akashi9
Misao Hachiya8
Mitsuteru Numazawa3
Michael W Epperly2
Herbert Archer2
7Makoto Akashi
6Misao Hachiya
5Akira Isada
5Nobuyuki Hizawa
5Kathleen C. Barnes

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1994
2015
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Health effects of radiation and other health problems in the aftermath of nuclear accidents, with an emphasis on Fukushima.
437 nuclear power plants are in operation at present around the world to meet increasing energy demands. Unfortunately, five major nuclear accidents have occurred in the past--ie, at Kyshtym (Russia [then USSR], 1957), Windscale Piles (UK, 1957), Three Mile Island (USA, 1979), Chernobyl (Ukraine [then USSR], 1986), and Fukushima (Japan, 2011). The effects… (More)
Exogenously-added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation
The vascular endothelium is important for the early and late effects observed in lethally irradiated tissue and organs. We examined the effects of exogenously added superoxide dismutase on cell survival and angiogenesis in lethally irradiated human primary umbilical vein endothelial cells. Cell survival was significantly improved in superoxide… (More)
The Medical Basis for Radiation-Accident Preparedness: Medical Management
The impact of any nuclear or radiological emergency with off-site consequences rapidly becomes of regional and global concern. The need for prompt international notification, information exchange, and cooperation (as well as international assistance in cases when the capabilities of a country Might be exceeded) calls for an international focal point and… (More)
Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors.
Aromatase, which is responsible for the conversion of androgens to estrogens, is a potential therapeutic target for the selective lowering of estrogen levels in patients with estrogen-dependent breast cancer. To develop a novel class of aromatase inhibitors, we tested series of 2- and 4-substituted (halogeno, methyl, formyl, methoxy, nitro, and amino)… (More)
Medical management of the consequences of the Fukushima nuclear power plant incident.
A huge earthquake struck the northeast coast of the main island of Japan on March 11, 2011, triggering a tsunami with 14-15 meter-high waves hitting the area. The earthquake was followed by numerous sustained aftershocks. The earthquake affected the nuclear power plant (NPP) in Fukushima prefecture, resulting in large amounts of radioactive materials being… (More)
The accident at the Fukushima Daiichi Nuclear Power Plant in 2011.
A huge earthquake struck the northeast coast of the main island of Japan on 11 March 2011, triggering a tsunami with more than 10-m-high waves hitting the area. The earthquake was followed by numerous sustained aftershocks. The earthquake and aftershocks left almost 16,000 people dead and more than 2,800 missing (as of 11 March 2014). The earthquake… (More)
Structure-activity relationships of estrogen derivatives as aromatase inhibitors. Effects of heterocyclic substituents.
Aromatase, which is responsible for the conversion of androgens to estrogens, is a potential therapeutic target for the selective lowering estrogen level in patients with estrogen-dependent breast cancer. We prepared and tested series of the pyridine- and other heterocyclic ring-containing derivatives of 2- and 4-aminoestrones, estrone, and estradiol,… (More)
[Radiation emergency medical preparedness in Japan--lessons learned from the Fukushima accident].
Although radiation exposure accidents fortunately occur only rarely, potential sources for exposure accidents can be found anywhere. When persons are accidentally exposed to radiation, physicians may be involved in their assessment and care; of course, their early diagnosis and dose assessment are crucial. After the criticality accident at Tokaimura in… (More)
Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates.
Our rationale is based on the finding that estrone 3-sulfamate (EMATE, 2d), a typical estrone sulfatase (ES) inhibitor, can be hydrolyzed and the pharmacological effect of the free estrogen contributes to the bioactivity of the sulfamate. A number of 3-sulfamoylated derivatives of the good aromatase inhibitors, 2- and 4-halogeno (F, Cl, and Br) estrones and… (More)
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