Takako Maki

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OBJECTIVE To clarify the observed variability of haloperidol disposition in patients with psychiatric disorders. DESIGN Retrospective population pharmacokinetic study. PARTICIPANTS 218 Japanese patients aged 16 to 82 years who provided 391 serum haloperidol concentrations. METHODS Routine clinical pharmacokinetic data gathered from patients receiving(More)
OBJECTIVE Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of(More)
BACKGROUND Circulating high-sensitivity C-reactive protein (CRP) is a good marker of chronic low-grade inflammation. The few studies that have addressed the relationship between coffee consumption and CRP concentrations report inconsistent findings. The authors of this study examined the relationship between coffee and green tea consumption and serum(More)
Objective. Observational studies have shown a protective association between coffee consumption and type 2 diabetes mellitus whereas caffeine or caffeinated coffee acutely deteriorates glucose tolerance. We investigated the effects of chronic drinking of instant coffee on glucose and insulin concentrations during a 75 g oral glucose tolerance test. Methods.(More)
BACKGROUND Children and adolescents with school phobia sometimes complain of severe and persistent headaches that are diagnosed as chronic daily headache (CDH). METHODS We investigated 24 children with CDH and school phobia, and 26 children with CDH but without school phobia. RESULTS Of 24 children with CDH and school phobia, 4% had chronic migraine(More)
Confusional migraine (CM) is recognized as a kind of pediatric migraine equivalent. We report that a 10-year-old girl had repeated attacks of confusional state and of migraine with aura. She suffered from total of six CM attacks and migraine attacks with aura almost once a month. Therefore, sodium valproate (VPA) was initiated to prevent these attacks. They(More)
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