Takako Hamano

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To clarify the mechanism of sensitivity to an endotoxin lipopolysaccharide LPS0111:B4, which causes severe liver injury in a variety of animals, we have developed an in vitro assay to measure Kupffer cell-mediated cytotoxicity in the human liver cell line, WRL68. This assay could detect the decrease in Kupffer cell activity induced by gadolinium chloride(More)
Effect of tunicamycin, an inhibitor of N-linked glycosylation, on prostaglandin (PG) F2α-stimulated phosphoinositide (PI) hydrolysis was examined in cultured rat astrocytes. Pretreatment of cultured astrocytes with tunicamycin (25–250 ng/ml) inhibited subsequent PGF2α (1 μM)-stimulated PI hydrolysis in concentration- and time-dependent manners. The(More)
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