Takahisa Hirose

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OBJECTIVE Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonists such as an exendin-4 has direct beneficial effects on the cardiovascular system. However, their effects on atherosclerogenesis have not been elucidated. The aim of this study was to investigate the effects of GLP-1 on accumulation of monocytes/macrophages on the(More)
1 OBJECTIVE—Recent studies identified accumulation of reac-tive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHODS—We investigated the effect of(More)
OBJECTIVE The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD. RESEARCH DESIGN AND METHODS Type 2 diabetic(More)
Although chronic pain due to diabetic neuropathy, defined as painful diabetic neuropathy (PDN), is a debilitating and distressing complication of diabetes, epidemiological data on PDN has been scarce, especially in Asia. We evaluated the prevalence of Japanese PDN and its impact on their quality of life (QOL) and metnal state. In addition, we examined to(More)
AIMS/INTRODUCTION The distinct effects of different statins on glycemic control have not been fully evaluated. In this open-label, prospective, cross-over clinical trial, we compared the effects of pitavastatin and atorvastatin on glycemic control in type 2 diabetic patients with hypercholesterolemia. MATERIALS AND METHODS A total of 28 Japanese type 2(More)
The level of intramyocellular lipids (IMCL) is a physiological marker of skeletal muscle function. (1)H-magnetic resonance spectroscopy (MRS) is an established method to measure IMCL contents in vivo. However, all of the MR systems do not always contain measurement instruments for (1)H-MRS, thus in a clinical setting, alternative methods for estimation of(More)
• We assessed the efficacy and safety of vildagliptin as add-on to on insulin, with or without concomitant metformin treatment in Japanese patients with type 2 diabetes mellitus. • Vildagliptin demonstrated consistent reductions in mean HbA1c compared to placebo throughout the study. Adjusted mean change in HbA1c from baseline to 12-week study endpoint was(More)
AIMS/INTRODUCTION 'Morningness' and 'eveningness' represent the sleep-wake patterns of the circadian rhythm might also affect glycemic control in patients with type 2 diabetes. The aim of this study was to examine the relationship between the morningness-eveningness trait and metabolic parameters. MATERIALS AND METHODS The study participants comprised 101(More)
Here, we analyzed the expression of the three members of the retinoid-like orphan receptor (ROR) nuclear receptor subfamily during adipocyte differentiation. RORa and ROR7 mRNA were up-regulated during adipocyte differentiation in preadipocyte Dl and 3T3-L1 cells, whereas RORIJ mRNA could not be detected. The induction of RORa and RORy mRNA succeeded the(More)
OBJECTIVE To examine whether hand contamination with fruit results in a false blood glucose (BG) reading using capillary fingertip blood sample. RESEARCH DESIGN AND METHODS The study subjects were healthy volunteers with normal glucose tolerance test. Capillary BG samples were collected from the fingertip after peeling orange, grape, or kiwi fruit,(More)