Takahiro Yamakawa

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Mice lacking modulator recognition factor-2 (Mrf-2; ARID5B) have less fat in brown and white adipose tissues, partly because of a defect in adipocyte differentiation. We have also shown that knockdown of Mrf-2 decreases the expression of the adipogenic transcription factors C/EBPalpha and PPARgamma, and inhibits adipogenesis in 3T3-L1 preadipocytes. Since(More)
Previous study showed that mice lacking modulator recognition factor-2 (Mrf-2) were lean, with significant decreases in white adipose tissue. One postulated mechanism for the lean phenotype in Mrf-2 knockout mice is a defect in adipogenesis. In order to investigate this further, we examined the effects of Mrf-2 deficiency on adipogenesis in vitro. In mouse(More)
This study demonstrated that ARID5B mRNA is present in mouse cardiomyocyte HL-1 cells, and that ARID5B siRNA constantly knocked down ARID5B gene expression to the 40% level of control. AMPKα2 protein was elevated in such ARID5B knockdown HL-1 cells, and this was accompanied by an increase in the level of phosphorylated AMPKα. Since AMPKα2 mRNA levels did(More)
The ability of heated scallop-shell powder (HSSP) to work against Listeria sp. biofilm formed at a low temperature was investigated. A biofilm of L. innocua ATCC 33090 was grown on a glass plate at 15˚C for 15 days, then immersed in HSSP slurry. Following treatment, the disinfection ability of the HSSP against the biofilm was non-destructively quantified by(More)
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