Takahiro Ueno

Noboru Fukuda7
Masayoshi Soma6
Taro Matsumoto4
Yoshiaki Matsumoto3
Hiroki Nagase3
7Noboru Fukuda
6Masayoshi Soma
4Taro Matsumoto
3Yoshiaki Matsumoto
3Hiroki Nagase
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INTRODUCTION The aim of this study was to investigate the association between the variation in expression profile of clock genes and obesity using peripheral blood mononuclear (PMN) cells. MATERIAL AND METHODS The subjects comprised 10 obese patients and 10 healthy volunteers. Blood was collected at different time-points during the day and levels of blood(More)
The presence of inflammation decreases local anesthetic efficacy, especially in dental anesthesia. Although inflammatory acidosis is most frequently cited as the cause of such clinical phenomena, this has not been experimentally proved. We verified the acidosis mechanism by studying the drug and membrane lipid interaction under acidic conditions together(More)
  • Masashi Taniguchi, Kyoko Fujiwara, Yuji Nakai, Toshinori Ozaki, Nobuko Koshikawa, Kojima Toshio +9 others
  • 2014
Gene amplification and/or overexpression of the transcription factor c-MYC, which binds to the E-box sequence (5'-CACGTG-3'), has been observed in many human tumors. In this study, we have designed 5 pyrrole-imidazole (PI) polyamides recognizing E-box, and found that, among them, Myc-6 significantly suppresses malignant phenotypes of human osteosarcoma MG63(More)
BACKGROUND Anderson's Disease (AD)/Chylomicron Retention Disease (CMRD) is a rare hereditary hypocholesterolemic disorder characterized by a malabsorption syndrome with steatorrhea, failure to thrive and the absence of chylomicrons and apolipoprotein B48 post-prandially. All patients studied to date exhibit a mutation in the SAR1B gene, which codes for an(More)
Implantation of mesenchymal stem cells (MSCs) has recently been reported to repair tissue injuries through anti-inflammatory and immunosuppressive effects. We established dedifferentiated fat (DFAT) cells that show identical characteristics to MSCs. We examined the effects of 106 of DFAT cells infused through renal artery or tail vein on monoclonal antibody(More)
A method to detect cracks near the surface of wooden boards has been developed where the change in surface temperature of the wood sample is monitored using an infrared camera following momentary heating by a flash. Cylindrical holes simulating cracks were drilled into the wood samples, and blackbody paint was painted onto the surface of the samples to(More)
Pyrrole–imidazole (PI) polyamides are nuclease-resistant novel compounds that inhibit transcription factors by binding to the minor groove of DNA. A PI polyamide that targets mouse ABCA1 and increases ABCA1 gene expression was designed and evaluated as an agent to increase plasma HDL concentration. A PI polyamide was designed to bind the activator protein-2(More)