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TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel.
It is demonstrated that human TMEM16F is an essential component of a Ca(2+)-activated Cl(-) channel with aCa(2+) sensitivity that is distinct from that of TMEM 16A/B and that it is not related to VSOR activity. Expand
TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.
It is concluded that TRPM7 represents the SSAC channel endogenously expressed in HeLa cells and that, by serving as a swelling-induced Ca(2+) influx pathway, it plays an important role in cell volume regulation. Expand
Swelling-Induced, Cftr-Independent Atp Release from a Human Epithelial Cell Line
In a CFTR-lacking human epithelial cell line, osmotic swelling induces ATP release and increases the cell surface ATP concentration over 10 μM, which is high enough to stimulate purinergic receptors, and the pathway of ATP release is distinct from the pore of the volume-sensitive outwardly rectifying Cl− channel. Expand
A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel.
It is concluded that an apoptosis-triggering anion conductance is carried by the volume-sensitive outwardly rectifying Cl(-) channel and that the channel activation on apoptotic stimulation with staurosporine, but not with Fas ligand or TNF-alpha, is mediated by ROS. Expand
Direct Mechano-Stress Sensitivity of TRPM7 Channel
It is concluded that the TRPM7 channel can be directly activated by mechano-stress in a manner independent of exocytosis-mediated incorporation of this channel protein into the plasma membrane. Expand
Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume
It is demonstrated that overexpression of murine TRPP3 channel in HEK293 cells, without coexpression of PDK1-like proteins, leads to robust channel activity and can act as a voltage-dependent, pH- and volume-sensitive plasma membrane cation channel. Expand
Impaired activity of volume‐sensitive Cl− channel is involved in cisplatin resistance of cancer cells
Impaired activity of the VSOR chloride channel is involved in the cisplatin resistance of KCP‐4 cancer cells, and restoration of the channel's functional expression by TSA treatment leads to a decrease in this drug's resistance. Expand
Testicular torsion–detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning
A new treatment, especially postconditioning, is proposed to prevent adverse effects of ischemia–reperfusion injury after testicular torsion–detorsion, which carries a significant risk of subsequent infertility. Expand
Dual roles of plasmalemmal chloride channels in induction of cell death
The volume regulatory anion channel plays, unless impaired, a cell-rescuing role in the necrotic process by ensuring RVD after swelling induced by necrotics insults, whereas normotonic activation of the anionChannel plays acell-killing roles in the apoptotic process by triggering AVD following stimulation with apoptosis inducers. Expand
TRPM4 regulates migration of mast cells in mice.
We demonstrate here that the transient receptor potential melastatin subfamily channel, TRPM4, controls migration of bone marrow-derived mast cells (BMMCs), triggered by dinitrophenylated human serumExpand