Takahiro Nishiyama

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We consider pairwise multiple comparisons and multiple comparisons with a control among mean vectors for high-dimensional data under the multivariate normality. For such cases, the statistics based on Dempster trace criterion are given, and also their approximate upper percentiles are derived by using Bonferroni’s inequality. Finally, the accuracy of their(More)
OBJECTIVE Herpes zoster is the most common infection in patients treated with bortezomib-containing regimens for multiple myeloma. Some clinical trials have reported on the use of acyclovir prophylaxis to decrease the incidence of herpes zoster. However, the appropriate acyclovir dose and duration of prophylaxis remain unclear. The primary objective of this(More)
Early relapse is a parameter that affects clinical outcomes in relapsed diffuse large B cell lymphoma (DLBCL). The prognostic value of lymphopenia following the completion of first-line therapy and the relationship between lymphopenia and early relapse are unknown. Therefore, we studied the role of absolute lymphocyte count (ALC) on early relapse. We(More)
Iron is an essential nutrient for every type of life on earth. However, excess iron is cytotoxic and can lead to an increased cancer risk in humans. Catalytic ferrous iron [Fe(II)] is an initiator of the Fenton reaction, which causes oxidative stress by generating hydroxyl radicals. Recently, it became possible to localize catalytic Fe(II) in situ with a(More)
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited. Here, we report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and(More)
In this article, we propose a test for making an inference about the blockdiagonal covariance structure of a covariance matrix in non-normal highdimensional data. We prove that the limiting null distribution of the proposed test is normal under mild conditions when its dimension is substantially larger than its sample size. We further study the local power(More)
We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, the usefulness of WT1 mRNA expression in(More)
Here, p(: Ω→ R) is the pressure, ∂Ω is the boundary, and n is the unit outward normal vector on ∂Ω. In the axisymmetric case, the existence of solutions to (1.2) was discussed as the problem of vortex rings in, for example, [2, 4, 5, 8]. Their methods were based on a variational principle for kinetic energy. By contrast, Vallis et al. [13] proposed a(More)