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Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
TLDR
It is shown that the agonist-activated AhR/Arnt heterodimer directly associates with oestrogen receptors ER-α and ER-β, which results in the recruitment of unliganded ER and the co-activator p300 to ostrogen-responsive gene promoters, leading to activation of transcription and oestrogensic effects.
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.
TLDR
A model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system is supported, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs.
Suppressive function of androgen receptor in bone resorption
TLDR
It is shown that inactivation of AR in mice using a Cre-loxP system-mediated gene-targeting technique caused bone loss in males but not in females, and results indicate that AR function is indispensable for male-type bone formation and remodeling.
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
TLDR
It is suggested that DEAD-box RNA helicase subunits are required for recognition of a subset of primary miRNAs in mDrosha-mediated processing.
Premature ovarian failure in androgen receptor-deficient mice.
TLDR
It is suggested that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome.
Brain masculinization requires androgen receptor function.
TLDR
It is suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling.
The androgen receptor in health and disease.
TLDR
This review summarized recent advances in understanding of the epigenetic mechanisms of AR action as well as newly recognized aspects of AR-mediated androgen signaling in both men and women offer a perspective on the use of animal genetic model systems aimed at eventually developing novel therapeutic AR ligands.
Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.
TLDR
This could be the first genetic study analyzing the roles of the genetic interactions between androgen and locally expressed growth factor signaling during the development of reproductive organs and indicates the novel functions of the Wnt/beta-catenin pathway as a locally expressed masculine effector.
DNA demethylation in hormone-induced transcriptional derepression
TLDR
The present findings suggest that methylation switching at the DNA level contributes to the hormonal control of transcription of the cytochrome p450 27B1 gene.
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