Takahiro Kawashima

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To determine the effects of noradrenergic neuronal activity on performance in continuous tasks requiring effortful attention, the performance of 23 male students in the Uchida-Kraepelin test (UKT) was examined. The UKT requires continuous arithmetic addition of single-digit figures for 25 min. The relationship of performance with saliva levels of(More)
Physiological studies on the monkey retrosplenial (RS) cortex have been few, and its functional role remains to be investigated. In the present study, activity of the RS cortex was investigated using radioactive 2-DG while the monkey was performing a visual tracking task with a delay (a delayed-response task) for 45 minutes. A remarkable increase in 2-DG(More)
We have developed a two-lever choice reaction-time (RT) task to investigate the behavioral and neural mechanisms of stimulus-response compatibility in rats. In the task, the rat pressed two levers with its forepaws during the preparation period of each trial, and then quickly responded to an air-puff stimulus on its left or right forepaw by releasing the(More)
The effects of alpha-tocopherol on neurons of fetal rat brain were studied in tissue culture. alpha-Tocopherol supported the survival and enhanced neurite extension of neurons cultured from cerebral cortex, hippocampus, striatum, and septum. The survival effect was observed at concentrations of 10(-9) to 10(-6) M. More than 60% of the cortical neurons could(More)
The topography of the commissural fibers in the corpus callosum (CC) of the cat was systematically investigated using the WGA-HRP method. WGA-HRP was injected into various parts of the cerebral cortex and locations of WGA-HRP-stained commissural fibers in the CC were examined. Commissural fibers were arranged in a topological fashion in the CC. Cortical(More)
Neurons from the central nervous system (CNS) of rat embryos die within several days when seeded at a low density of 10(4) cells/cm2 and cultured in a serum-free defined medium. Using these culture systems, we searched for agents to promote the survival of these neurons. As a consequence, a fat-soluble vitamin, vitamin K1, was found to possess such kind of(More)
The effects of a specific GABAB receptor antagonist, p-(3-aminopropyl)-p-diethoxymethyl-phosphonic acid (CGP 35348), on pyramidal tract neuron responses to transcallosal stimulation were investigated in the cat motor cortex in vivo. The paired-pulse method was used to obtain more insight into the role of GABAB receptors. At a 200-ms inter-stimulus interval(More)
The effects of a specific GABAB receptor antagonist, p-(3-aminopropyl)-p-diethoxymethyl-phosphonic acid (CGP 35348), on pyramidal tract neuron responses to transcallosal stimulation were investigated in the cat motor cortex in vivo. Iontophoretic application of CGP 35348 significantly increased the number of spikes from 10.3 +/- 4.4 (control; n = 27; mean(More)