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Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
- T. Nakada, Kazuma Kiyotani, +8 authors T. Kamataki
- The Journal of toxicological sciences
- 1 June 2012
We previously found that genetic polymorphism in cytochrome P450 2A6 (CYP2A6) is one of the potential determinants of tobacco-related lung cancer risk. It has been reported that the plasma… Expand
Microbial asymmetric oxidation of 2-butyl-1,3-propanediol
- K. Mitsukura, T. Uno, T. Yoshida, T. Nagasawa
- Chemistry, Medicine
- Applied Microbiology and Biotechnology
- 24 April 2007
Microbial asymmetric oxidation of 2-butyl-1,3-propanediol was investigated for an efficient synthesis of S- and R-enantiomers of 2-hydroxymethylhexanoic acid (2-HMHA). From an intensive survey of the… Expand