Takahiko Nakamura

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We show that the mouse macrophage-restricted F4/80 protein is not required for the development and distribution of tissue macrophages but is involved in the generation of antigen-specific efferent regulatory T (T reg) cells that suppress antigen-specific immunity. In the in vivo anterior chamber (a.c.)-associated immune deviation (ACAID) model of peripheral(More)
Following inoculation of Ag into the anterior chamber (a.c.), systemic tolerance develops that is mediated in part by Ag-specific efferent CD8(+) T regulatory (Tr) cells. This model of tolerance is called a.c.-associated immune deviation. The generation of the efferent CD8(+) Tr cell in a.c.-associated immune deviation is dependent on IL-10-producing,(More)
We examined the biological and histologic characteristics of a new experimental model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats. Rats were given a single intraperitoneal injection of 500 mg/100 g body weight ofl-arginine. At 12–24 hr after the arginine injection, serum levels of amylase, lipase, and anionic(More)
In this paper, a wearable walking support system for people who have difficulties in walking because of weakened lower extremities is proposed. We propose a model-based control algorithm for the wearable device without using biological signals, that is, the knee joint support moment is calculated as a function of the user’s posture and the GRF based(More)
In this paper, to construct the system, which can assist daily activities of physically weak person more smartly, we propose a new wearable antigravity muscles support system, which supports antigravity muscles based on the posture and motion of user. In this system, a dynamics-based control algorithm for the device without using biological signals is(More)
The therapeutic effect and the mechanism of action of the synthetic trypsin inhibitor camostate were studied in a rat model of acute interstitial pancreatitis induced by four subcutaneous injections of 20 μg/kg body weight of cerulein at hourly intervals. Rats with acute pancreatitis were given either 100 mg/kg body weight camostate or volume- and(More)
1. Chandra NS, Torres MF, Winthrop KL, et al. Cluster of Mycobacterium chelonae keratitis cases following laser in-situ keratomileusis. Am J Ophthalmol 2001;132:819–830. 2. Freitas D, Alvarenga L, Sampaio J, et al. An outbreak of Mycobacterium chelonae infection after LASIK. Ophthalmology 2003;110: 276–285. 3. Chung MS, Goldstein MH, Driebe WJ, Schwartz BH.(More)
In a model of peripheral tolerance called anterior chamber-associated immune deviation (ACAID), the differentiation of the T regulatory cells depends on NKT cells and occurs in the spleen. In this study, we show that NKT cells that express the invariant (i) TCR and are the CD1d-reactive NKT cells (required for development of peripheral tolerance) actually(More)
This paper considers bifurcation phenomena in a simplified hysteresis neural network. The network consists of three cells and has three control parameters. We have discovered that the simple system exhibits various attractors: stable equilibria, periodic orbits, and chaos. Since the system is piecewise linear, the return map and Lyapunov exponents are(More)