Takahide Ito

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OBJECTIVE The relationship between left ventricular (LV) systolic dysfunction and cognitive impairment (CI) has been discussed. The present study was performed to elucidate the relation between cognitive function and LV diastolic dysfunction in patients with various cardiovascular diseases. METHODS AND RESULTS The Mini-Mental State Examination (MMSE) and(More)
Besides regulating calcium-phosphate metabolism, fibroblast growth factor-23 (FGF23) and Klotho have been proposed to have other roles in heart and vasculature. For example, FGF23 has been associated with cardiac hypertrophy and reduced left ventricular ejection fraction among patients with chronic kidney disease and cardiovascular disorders. The purpose of(More)
BACKGROUND Postsystolic shortening (PSS) is considered myocardial shortening after the point of aortic valve closure and can be observed physiologically in healthy individuals. However, the incidence and magnitude of PSS in myocardial disorders have not been investigated. OBJECTIVES We performed strain imaging to characterize PSS in patients with(More)
In patients with nonvalvular atrial fibrillation, the electrocardiographic fibrillatory wave reflects the structural and electrical remodeling of the atria. This study examined whether the fibrillatory wave amplitude could predict the risk of thromboembolism and demonstrated that this amplitude was related to the duration of atrial fibrillation. We also(More)
A 62-year-old female with palpitations was admitted to hospital where she recorded 12,299 monofocal ventricular premature contractions (VPCs) in 24 h and nonsustained ventricular tachycardia (VT) on exertion. She had hypokalemia with renal potassium wasting, a chloride-resistant metabolic alkalosis, elevated plasma renin, elevated plasma aldosterone(More)
Angiotensin II receptor blockers (ARBs) are suggested to be protective against myocardial hypertrophy and fibrosis, although such beneficial effects remain to be elucidated in the human heart. The aim of the present study was to examine the effect of a novel ARB, olmesartan, on myocardial function of the left ventricle in patients with mildto-moderate(More)
BACKGROUND Hypoxia has been suggested to affect myocardial contractile function in patients with obstructive sleep apnea (OSA). We sought to determine whether myocardial contractile reserve (MCR), as evaluated by echocardiographic tissue Doppler imaging with dobutamine stress (TDDS), might be depressed in OSA patients. METHODS Thirty patients with(More)
A 46-year-old man with a clinical diagnosis of dilated phase of hypertrophic cardiomyopathy was followed up at our hospital for 26 years. His refractory congestive heart failure gradually worsened over several years, and he was unresponsive to conventional medications. He then underwent left ventriculoplasty. Biochemical and genetic investigations of the(More)
The aim of the present study was to examine subclinical effect of the severity of obstructive sleep apnea (OSA) on myocardial structural changes and function using echocardiographic integrated backscatter and tissue Doppler imaging. Fifty patients with suspected OSA underwent overnight polysomnography and echocardiographic assessment. The myocardial(More)
BACKGROUND Several studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH(More)