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HTLV-1 infection of humanized NOG mice has been demonstrated to recapitulate the development of ATL-like symptoms within several months of infection. Infected human T-cells in these mice start to proliferate vigorously in a couple weeks after infection and the mice die of ALT-like lymphoproliferative disorder. Thus, this mouse model should provide a potent(More)
Tax has pleiotropic actions that induce proliferation and inhibit apoptosis of T-cells and thus is considered to play a critical role in leukemogenesis. However, Tax expression is frequently lost in fresh adult T-cell leuke-mia (ATL) cells by genetic changes or epigenetic modifications of proviral genome. To clarify the significance of tax gene in(More)
Risk for HAM/TSP development is known to differ among the subtypes of HTLV-1. In Japan, incident rate of HAM/ TSP in carrier people infected with cosmopolitan type A is 2.5 times higher than those with cosmopolitan type B. Although HTLV-1 of cosmopolitan type A is also prevalent in Jamaica and northern part of Iran, the rate of HAM/TSP development in this(More)
A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period In the peripheral blood leukocytes (PBL) infected with human T-cell leukemia virus type-1 (HTLV-1), which causes HTLV-1 associated diseases(More)
HTLV-1 infection leads to adult T-cell leukemia (ATL) after long latent infection period. We have established an HTLV-1-infected humanized NOG mouse model to analyze the mechanism of ATL development. Huma-nized mice were inoculated with Jurkat-based HTLV-1 producing cells, JEX, into peritoneal cavity to infect human T-cells with HTLV-1. Infected T-cells(More)
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