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LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
Leucine-rich repeat kinase 2 (LRRK2), a large protein kinase containing multi-functional domains, has been identified as the causal molecule for autosomal-dominant Parkinson's disease (PD). In theExpand
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Use of ADME studies to confirm the safety of ε-polylysine as a preservative in food
Abstract e-Polylysine is a homopolymer of l -lysine, containing approximately 30 l -lysine subunits, as synthesized in aerobic bacterial fermentation by Streptomyces albulus. e-Polylysine is approvedExpand
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Stimulatory effect of α‐synuclein on the tau‐phosphorylation by GSK‐3β
Hyperphosphorylation of tau protein (tau) causes neurodegenerative diseases such as Alzheimer’s disease (AD). Recent studies of the physiological correlation between tau and α‐synuclein (α‐SN) haveExpand
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Leucine‐rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase‐3β
Leucine‐rich repeat kinase 2 (LRRK2) has been identified as the causal molecule for autosomal‐dominant Parkinson's disease (PD). Experimental evidence indicates that LRRK2 may play an important roleExpand
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Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate Kinase Family Protein, in Epithelial-Mesenchymal Transition in LLc-PK1 Renal Epithelial Cells
Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase adaptor family of proteins, some of which are involved in the regulation of epithelial-to-mesenchymal transitionExpand
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  • Open Access
The role of the interaction of the vinculin proline-rich linker region with vinexin &agr; in sensing the stiffness of the extracellular matrix
ABSTRACT Although extracellular matrix (ECM) stiffness is an important aspect of the extracellular microenvironment and is known to direct the lineage specification of stem cells and affect cancerExpand
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Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behavior
The extracellular matrix (ECM) is a major regulator of cell behavior. Recent studies have indicated the importance of the physical properties of the ECM, including its stiffness, for cell migrationExpand
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Immunohistochemical localization in rat gastrointestinal tract of a sialomucin species recognized by HCM31, a new anti-mucin monoclonal antibody
It has been recognized that distinct mucus secreting cells of the gastrointestinal tract express specific type of mucins. We have recently demonstrated that a kind of sialomucin specifically stainedExpand
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Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation
ABSTRACT Vinexin, c-Cbl associated protein (CAP) and Arg-binding protein 2 (ArgBP2) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs).Expand
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Cellular force assay detects altered contractility caused by a nephritis‐associated mutation in nonmuscle myosin IIA
Recent progress in understanding the essential roles of mechanical forces in regulating various cellular processes expands the field of biology to one where interdisciplinary approaches withExpand
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