Clozapine has improved efficacy relative to typical antipsychotics in schizophrenia treatment, particularly regarding emotional symptoms. However, the mechanisms underlying its therapeutic benefits remain unclear. Using a methamphetamine-sensitised rat model, we measured changes in dopamine levels in the amygdalae in response to a fear-conditioned cue,… (More)
Benzodiazepines are widely used as anti-anxiety drugs and sleeping drugs. On the other hand, it is also true that use disorders such as abuse or dependence is often a problem. Including the distinctive usual dose depends on the BZ drugs use disorders, I outlined the actual situation, diagnostic criteria, and the treatment.
BACKGROUND In 2010, foot-and-mouth disease (FMD) occurred for the first time in a decade in Japan. Movement or shipment of people and animals around infected farms was restricted; however these contingency measures proved insufficient to prevent FMD spread. Consequently, a total of 292 farms were confirmed as infected during this outbreak. We conducted a… (More)