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Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
TLDR
It is found that angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in both mice and humans. Expand
Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.
TLDR
It is found that INSM1 was not expressed in non-small-cell lung cancer and some SCLC cell lines expressing Notch1-Hes1, and by forced/knockdown expression of Notch 1 or Hes1 genes, it was revealed that Notch2-HES1 signaling suppressed IN SM1, as well as ASCL1 and BRN2. Expand
Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid‐induced cell differentiation
TLDR
It is shown that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid‐induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinic acid receptor and activation transcription factor‐2 (ATF‐2). Expand
HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer.
TLDR
It is reported that High-mobility group A (HMGA1) is induced by the Wnt/beta-catenin pathway and maintains proliferation of gastric cancer cells and is a downstream target of the WNT/ beta-catanin pathway. Expand
Dual Effects of TRAIL in Suppression of Autoimmunity: The Inhibition of Th1 Cells and the Promotion of Regulatory T Cells
TLDR
The data suggest that TRAIL suppresses autoimmunity by two mechanisms: the inhibition of Th1 cells and the promotion of Tregs. Expand
Effects of Denervation on Neuromuscular Junctions in the Thyroarytenoid Muscle
TLDR
The effects of denervation on muscle fibers and neuromuscular junctions of the rat thyroarytenoid muscle with a histochemical method to monitor the status of degenerative NMJ is evaluated. Expand
The pathological significance of Notch1 in oral squamous cell carcinoma
TLDR
Results indicate that altered expression of Notch1 is associated with increased cancer progression and that notch1 regulates the steps involved in cell metastasis in OSCC, and inactivating Notch signaling with GSI could therefore be a useful approach for treating patients with OSCC. Expand
Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinoma.
TLDR
Notch1 up regulation has an inhibitory effect on cell growth and NE differentiation in SCLC, with induction of an epithelial-like morphology of cells in tissue samples. Expand
Aberrant Nuclear Localization and Gene Mutation of β-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development
TLDR
It is indicated that up-regulating disturbances in the Wnt signaling pathway, including mutation of the β-catenin gene, underlie tumorigenesis of L-FLAC/WDFA and may be a common denominator for the development of tumors with morular formation from a variety of anatomic sites. Expand
Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
TLDR
It is proposed that Angptl2 contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies. Expand
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