Taiwo Olayemi Elufioye

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OBJECTIVE To investigate the toxicity of an ethanolic extract of the aerial parts of Tithonia diversifolia, used in Nigeria to treat malaria, in rats. MATERIALS AND METHODS A 70% ethanol extract was administered orally to adult Wistar rats at various dosages (400-1600 mg/kg) and the animals sacrificed and various organs examined at a range of times from(More)
Ethanolic extracts of the aerial part of Tithonia diversifolia and the stem bark of Crossopteryx febrifuga were investigated against early, residual (repository) and established malaria infections in vivo using Swiss albino mice at a dose range of 50-400 mg/kg per day. Chloroquine at 5 mg/kg per day was used as the positive control for the early and(More)
Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the(More)
BACKGROUND This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer(More)
BACKGROUND This study was conducted to determine the antioxidant and acetylcholinesterase inhibitory activities of the leaf extract and different fractions of Albizia adianthifolia (Schumach.) W. Wright, and also to identify and quantify some phenolic compounds in the extract. METHODS The antioxidant and acetylcholinesterase inhibitory activities of the(More)
Spondias mombin has been used in traditional medicine for the management of several diseases, including memory loss. This study aimed to evaluate the cholinesterase inhibitory activity of the methanol extract of the leaves and its derived fractions, as well as carry out detailed phytochemical investigations leading to the isolation and characterization of(More)
BACKGROUND This study determined the cytotoxic effects of root and stem bark extracts, fractions, and isolated compounds derived from Pseudocedrela kotschyi on HeLa, MCF-7, and RD cells. MATERIALS AND METHODS The cytotoxic activity was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay against three cell lines(More)
BACKGROUND Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folklore documented its use in neuro-behavioural despairs. OBJECTIVE This study was conducted to investigate the neuro-pharmacological potentials of Buchholzia coriacea (MEBC) seed extract in the laboratory rodents. METHODOLOGY Methanol(More)
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