Taitan Nguyen

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Diaphragm remodeling associated with chronic obstructive pulmonary disease (COPD) consists of a fast-to-slow fiber type transformation as well as adaptations within each fiber type. To try to explain disparate findings in the literature regarding the relationship between fiber type proportions and FEV 1 , we obtained costal diaphragm biopsies on 40 subjects(More)
BACKGROUND Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expression of slower isoforms of myosin heavy chain (MHC), it has been difficult to demonstrate a shift in MHCs in an animal model that(More)
We described a new technique of orotracheal intubation in the rat. This technique is performed under direct vision by transillumination to obtain a better view of the rat's small and distant vocal cords. We also emphasize overextension of the neck to allow for a more direct path to the animal's trachea. This technique is easily learned, is atraumatic, and(More)
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