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Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
TLDR
A 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covod-19 who were also seen in the same intensive care unit are described.
Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia
TLDR
The immunological changes of coronaviruses like SARS, MERS and other viral pneumonia similar to SARS-CoV-2 are reviewed and the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed.
Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
TLDR
The results indicate that, besides CD4+ cell count rise, an efficient control of HIV replication may allow qualitative modifications of theCD4+ repertoire balance.
Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates
TLDR
Peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597–603 epitope, an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infections.
Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
TLDR
Several small molecules were identified that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.
COVID-19: towards understanding of pathogenesis
TLDR
The progression of COVID-19 was associated with a continuous decrease in lymphocyte count and significant elevation of neutrophils, and inflammatory markers were markedly elevated including C-reactive protein, ferritin, interleukin (IL)-6, IP-10, MCP1, MIP1A, and TNFα.
High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019
TLDR
Results from 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery suggest randomized studies of high- dose IVIg should be considered in deteriorating patients infected with CO VID-19.
IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus
TLDR
It is suggested that IL- 17 plays an important role in S-OIV-induced acute lung injury and that monoclonal antibodies against IL-17 could be useful as a potential therapeutic remedy for future S- OIV H1N1 pandemics.
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