Taiji Sakamoto

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Choroidal neovascularization (CNV) is directly related to visual loss in some eye diseases, such as age-related macular degeneration. Although several human histological studies have suggested the participation of macrophages in CNV formation, the precise mechanisms are still not fully understood. In this study, we elucidated the role of ocular-infiltrating(More)
To examine the transition to ureogenesis, the gobiid fish Mugilogobius abei was immersed in 2 mmol l(-)(1) NH(4)HCO(3) or a (15)N-labelled ammonia solution [1 mmol l(-)(1) ((15)NH(4))(2)SO(4), pH 8.0] for 4-8 days. When exposed to 2 mmol l(-)(1) NH(4)HCO(3) or (15)N-labelled ammonia solution for 4 days, the rate of urea excretion increased to seven times(More)
Photoreceptor degeneration is the most critical cause of visual impairment in age-related macular degeneration (AMD). In neovascular form of AMD, severe photoreceptor loss develops with subretinal hemorrhage due to choroidal neovascularization (CNV), growth of abnormal blood vessels from choroidal circulation. However, the detailed mechanisms of this(More)
Purpose: To determine the effect of a triamcinolone-assisted pars plana vitrectomy (PPV) on the visibility of hyaloid during surgery and the postoperative clinical outcome. Methods: Thirty-one patients with proliferative retinal disease [8 with diabetic macular edema (DME), 10 with proliferative diabetic retinopathy (PDR), 13 with proliferative(More)
PURPOSE To evaluate the effectiveness of intravitreal triamcinolone acetonide (IVTA) on the reduction of diffuse diabetic macular edema with different optical coherence tomographic patterns. METHODS One hundred and thirty-five eyes with diffuse diabetic macular edema without any treatment that had received a single dose (4 mg in 0.1 mL) of IVTA were(More)
PURPOSE To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography (OCT) and to investigate the relationship between postoperative VF defects and RNFL damage. DESIGN Retrospective interventional case(More)
Matrix metalloproteinases (MMPs) are endopeptidases that degrade the extracellular matrix (ECM) and are involved in the pathogenesis of retinal degeneration along with tissue inhibitors of metalloproteinases (TIMPs). The present study examined the expression and activation of two specific members of MMPs (MMP-2 and MMP-9) and their related inhibitors(More)
Background: This study was designed to investigate the influence of intravitreal indocyanine green (ICG) on retinal morphology and function. Methods: Brown Norway rats eyes (n=24) were vitrectomized by the injection of 0.05 ml of 100% SF6 gas. Two weeks later, ICG solution was injected into the vitreous cavity of vitrectomized eyes at a dose of 25 mg/ml,(More)
PURPOSE We describe a case demonstrating a submacular deposition of triamcinolone acetonide (TA) after a TA-assisted vitrectomy for retinal detachment. DESIGN Interventional case report. METHODS A 48-year-old Japanese man with rhegmatogenous retinal detachment in his left eye underwent a TA-assisted vitrectomy, endolaser photocoagulation, and sulfur(More)
OBJECTIVES To report the findings on a patient cohort with visual field defects after macular hole surgery with indocyanine green (ICG)-assisted internal limiting membrane peeling and to investigate the correlation between the defects and the use of ICG. DESIGN Retrospective, noncomparative interventional case series. PARTICIPANTS Thirty-nine eyes of 38(More)