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To investigate the inhibitory effect of hyaluronan (HA) on mechanical stress- induced expression of a disintegrin and metalloproteinase with thrombospondin type1 motifs (ADAMTS)-4, -5 and matrix metalloproteinase (MMP)-13 by human chondrocytes. Normal human articular chondrocytes were pre-incubated with or without 1.0 mg/mL HA (2700 kDa) for 12 h at 37 °C(More)
The importance of surgical resection for patients with supratentorial low-grade glioma (LGG) remains controversial. This retrospective study of patients (n = 153) treated between 2000 to 2010 at a single institution assessed whether increasing the extent of resection (EOR) was associated with improved progression-free survival (PFS) and overall survival(More)
R egular consumption of fish containing omega-3 fatty acids—but not fried fish—reduces the risk of atrial fibrillation, according to the results of a Harvard study.* Atrial fibrillation, the most common arrhythmia in clinical praaice, affects more than 2 million Americans. Risk factors, including valvular or coronary heart disease and higher systolic blood(More)
Six groups of pregnant dams were each fed a 20%, 12%, and 6% protein diet with and without caffeine (2 mg/100 g b.wt), starting on day 7 of gestation. Dams of each group were injected with two successive daily doses of 3H-thymidine in an overlapping series beginning on day 7 and ending on day 16 of gestation. At day 15 postbirth, brains of the offspring(More)
Six groups of pregnant dams were fed a 20%, 12%, and 6% protein diet with and without caffeine (2 mg/100 g b.wt.), starting on day 7 of gestation. At day 18 of gestation, randomly selected dams of each group were used to record prenatal fetal behavior. The remaining dams were continuously fed their respective diets until the birth of their pups. Upon(More)
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