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We report a method of inducing antigen production in dendritic cells by in vivo targeting with lentiviral vectors that specifically bind to the dendritic cell–surface protein DC-SIGN. To target dendritic cells, we enveloped the lentivector with a viral glycoprotein from Sindbis virus engineered to be DC-SIGN–specific. In vitro, this lentivector specifically(More)
Development of methods to engineer gamma-retroviral vectors capable of transducing target cells in a cell-specific manner could impact the future of the clinical application of gene therapy as well as the understanding of the biology of transfer gene vectors. Two molecular events are critical for controlling the entry of gamma-retroviral vectors to target(More)
In women, pain symptoms and nociceptive thresholds vary with the reproductive cycle, suggesting the role of estrogen receptors (ERs) in modulating nociception. Our previous data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root ganglion(More)
BACKGROUND Cell-cell communication occurs via a variety of mechanisms, including long distances (hormonal), short distances (paracrine and synaptic) or direct coupling via gap junctions, antigen presentation, or ligand-receptor interactions. We evaluated the possibility of neuro-hormonal independent, non-diffusible, physically disconnected pathways for(More)
We propose an emotional facial avatar that portrays the user’s facial expressions with an emotional emphasis, while achieving visual and behavioral realism. This is achieved by unifying automatic analysis of facial expressions and animation of realistic 3D faces with details such as facial hair and hairstyles. To augment facial appearance according to the(More)
Here, we report highly enhanced electrochemiluminescence (ECL) of luminol in the presence of H2O2 on indium tin oxides (ITOs) modified with both of dendrimer-encapsulated Pt nanoparticles (Pt DENs) and chemically converted graphenes (CCGs). The ITO electrodes were electrochemically modified with size-monodisperse Pt DENs via electrooxidative grafting of the(More)
We propose a system that classifies a user's facial expressions captured by a webcam and applies notable characteristics of the classified expression to an animated 3D facial avatar. The facial avatar is composed of multiple 3D models where a face model is combined with accessorial models such as facial hair. Such accessorial models are used to decorate the(More)
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