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Seizures have been reported to modify neural development in the immature brain. In this study, we attempted to determine whether pentylenetetrazol (a GABAergic receptor antagonist, PTZ)-induced seizures influence cell proliferation in zebrafish larvae (5 and 15 days of post-fertilization), using bromodeoxyuridine (BrdU) to label dividing cells. In the(More)
Histone deacetylase inhibitors (HDACIs) alter gene expression epigenetically by interfering with the normal functions of HDAC. Given their ability to decrease Aβ levels, HDACIs are a potential treatment for Alzheimer's disease (AD). However, it is unclear how HDACIs alter Aβ levels. We developed two novel HDAC inhibitors with improved pharmacological(More)
The tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, is a novel amyloid-binding small molecule that can penetrate the blood-brain barrier and protect cells from Aβ-induced toxicity. However, the effects of Aβ-targeting molecules on other cellular processes, including those that modulate synaptic plasticity, remain unknown. We report here(More)
Matrix metalloproteinases (MMPs) are zinc dependent endopeptidases that can be released from neurons in an activity dependent manner to play a role in varied forms of learning and memory. MMP inhibitors impair hippocampal long term potentiation (LTP), spatial memory, and behavioral correlates of drug addiction. Since MMPs are thought to influence LTP(More)
The epithalamic lateral nucleus of the habenula (LHb) plays a key role in regulating firing of dopamine and serotonin neurons in the midbrain and is thereby involved in various cognitive and affective behaviors. It is not yet clear, however, from where the LHb receives cognitive and affective information relevant to its regulation of the midbrain(More)
A base of clearly defined product information is a key foundation for an e-commerce system. The manipulation and exchange of semantically enriched and precise product information can enhance the quality of an e-commerce system and offer a high level of inter-operability with other systems. Product information consists of product attributes and the(More)
This paper proposes a novel way of automatically developing data warehouse configuration in rule-based CRM systems. Rule-based CRM systems assume that marketing activities are represented as a set of IF-THEN rules. Currently, to provide good quality CRM functionalities, CRM systems seek to combine conventional CRM methodologies with data warehousing(More)
A base of clearly defined product information is a key foundation for an e-commerce system. The manipulation and exchange of semantically enriched and precise product information can enhance the quality of an e-commerce system and offer a high level of interoperability with other systems. Product information consists of product attributes and the(More)
An ontology-based product-recommender system can help catalog administrators in B2B marketplaces maintain up-to-date product databases by acquiring mapping information between the new product data and existing data. The proposed approach is keyword-based and independent of the underlying physical structure of product ontology. With a Bayesian belief network(More)
Visual and somesthetic cues are used for spatial processing in the posterior parietal cortex (PPC) of the mammalian brain. In rats, somatic information collected by the mystacial whiskers is critically involved in constructing a neural representation of the external space. Here, we delineated the topography of the cortical pathway from the primary(More)