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Structurally Conserved Amino Acid W501 Is Required for RNA Helicase Activity but Is Not Essential for DNA Helicase Activity of Hepatitis C Virus NS3 Protein
ABSTRACT Hepatitis C virus (HCV) is a positive-strand RNA virus that encodes a helicase required for viral replication. Although HCV does not replicate through a DNA intermediate, HCV helicaseExpand
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A 1.35V 4.3GB/s 1Gb LPDDR2 DRAM with controllable repeater and on-the-fly power-cut scheme for low-power and high-speed mobile application
We present an on-the-fly power-cut scheme that can be applied to mobile DRAM without any special modes and a global data-line repeater scheme to reduce the data- line delay. Expand
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Phenothiazine-phenylquinoline donor-acceptor molecules: effects of structural isomerism on charge transfer photophysics and electroluminescence.
Large differences in the intramolecular charge-transfer fluorescence quantum yields and electroluminescence efficiencies were observed among the isomeric donor-acceptor moleculesExpand
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Preparation of 5-Alkenyl- and 5-Dienyl-2-pyrrolidinone Derivatives
Abstract Glutamic acid is readily converted into N-butenyl-2-pyrrolidi-none-5-carboxaldehyde. The novel butenyl protecting group allows the synthesis of this aldehyde which can be olefinated usingExpand
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A new lactam protecting group
N-Alkenyl and N-alkoxymethyl lactams are impervious to many reagents and are useful protecting groups for lactams. Conversion to the corresponding 2-ethoxy iminium salt and hydrolysis in neutralExpand
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Asymmetric synthesis of (S)-4-aminohex-5-enoic acid: a potent inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase
The potent inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T), 4-aminohex-5-enoic acid (vinyl GABA), has been synthesized with excellent enantioselectivity in six steps fromExpand
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Abstract The reaction rate of Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing an aldehyde, diethyl malonate, P2O5, piperidine, and chlorobenzeneExpand
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Photochemical cleavage of cyclohexa-2,4-dienones under irradiation with visible light
Abstract 2,4,6-Trimethylcyclohexa-2,4-dien-1-one derivatives undergo ring cleavage to furnish amides on irradiation with visible light in the presence of various amines. Seven different amidesExpand
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Preparation and Reactions of 1,1-Di(Phenylthio)Cyclobutane Derivatives from 1-(Phenylthio)-1-Cyclopropane Carbinols
Abstract 1-(Phenylthio)cyclopropylcarbinyl alcohols are converted to 2-alkyl-1, 1-di(phenylthio)cyclobutane derivatives upon treatment with 48% HBr and ZnBr2. Heating with copper triflate and Hunig'sExpand
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Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes
Abstract The reaction rate of Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing ethyl cyanoacetate, an aldehyde, P2O5, piperidine, and chlorobenzeneExpand
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