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Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying it to human LC originating from lung cancer, the most common cause of CNS metastasis.(More)
BACKGROUND Long-term maintenance of avian primordial germ cells (PGCs) in vitro has tremendous potential because it can be used to deepen our understanding of the biology of PGCs. A transgenic bioreactor based on the unique migration of PGCs toward the recipients' sex cord via the bloodstream and thereby creating a germline chimeric bird has many potential(More)
OBJECTIVE The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. MATERIALS AND METHODS Twenty patients with(More)
Pseudoprogression is a major diagnostic dilemma in current treatment protocols for malignant gliomas that involve concurrent chemoradiotherapy. We hypothesized that methylation-specific multiplex ligation probe amplification (MS-MLPA), an assay that permits semiquantitative evaluation of promoter methylation, may be used to diagnose pseudoprogression based(More)
This study was performed to evaluate the incidence of seizures with its implications on disease progression and the diagnostic value of post-ictal magnetic resonance images (MRI) during the management of high-grade gliomas (HGGs). A total of 406 consecutive patients with newly diagnosed HGGs were retrospectively reviewed. The incidence of seizures during(More)
We propose a low-complexity minimum mean square error (MMSE) transmit filter design for the coordinated beamforming (CB) in the coordinated multipoint (CoMP) under the practical per-antenna power constraint (PAPC). The proposed design is based on the nonlinear Gauss-Seidel type algorithm in which the transmit filters for given receive filters are computed(More)
We study the outage performance of an amplify-and-forward (AF) cooperation with full duplex relaying (FDR). When there exists a non-negligible direct link or residual self interference (RSI), full duplex relaying turns the effective channel into a frequency selective channel. Assuming minimum mean squared error decision feedback equalization (MMSE-DFE) at(More)
PURPOSE We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL). EXPERIMENTAL DESIGN We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines. RESULTS Multivariate analysis showed low miR-146a expression (P < 0.001; HR = 13.110), primary(More)
Distributed sum-rate-maximizing covariance matrices design for full-duplex multi-input multi-output communication is considered, where the information of the loopback interference channels cannot be exchanged reliably due to their large dynamic ranges. We propose a structured covariance matrices design which finds the optimal balance between the two(More)
We investigated the role of somatic mutations and a common single nucleotide polymorphism (SNP) in the hTERT promoter region on hTERT expression and clinical outcomes. The hTERT promoter region was sequenced from 48 glioblastomas. hTERT expression was analyzed by quantitative real time-PCR. The association between hTERT promoter genetic changes and other(More)