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An investigation has been made into the effect produced by photo-induced pyrimidine cross-links upon the secondary structure of DNA. We have studied the effect of uv irradiation upon the B in equilibrium A transition in DNA brought about by a change of solvent from 70 to 80% ethanol. Circular dichroism (CD) was used to monitor the conformational changes.(More)
High-contrast, 30 fs, 1.5 PW laser pulses are generated from a chirped-pulse amplification (CPA) Ti:sapphire laser system at 0.1 Hz repetition rate. The maximum output energy of 60.2 J is obtained, at a pump energy of 120 J, from a booster amplifier that is pumped by four frenquency-doubled Nd:glass laser systems. During amplification, parasitic lasing is(More)
Coherent short-wavelength radiation from laser-plasma interactions is of increasing interest in disciplines including ultrafast biomolecular imaging and attosecond physics. Using solid targets instead of atomic gases could enable the generation of coherent extreme ultraviolet radiation with higher energy and more energetic photons. Here we present the(More)
We demonstrate a long-term operation with reduced phase noise in the carrier-envelope-phase (CEP) stabilization process by employing a double feedback loop and an improved signal detection in the direct locking technique [Opt. Express 13, 2969 (2005)]. A homodyne balanced detection method is employed for efficiently suppressing the dc noise in the f-2f beat(More)
We report on the generation of 1.0 PW, 30 fs laser pulses at a 0.1 Hz repetition rate from a chirped-pulse amplification Ti:sapphire laser system. The energy of the laser pulses is amplified up to 47 J in a final three-pass booster amplifier having 96 J pump energy. To the best of our knowledge, this is the first petawatt Ti:sapphire laser system at a 0.1(More)
We have demonstrated broadening of the phase-matching bandwidth in a periodically poled Ti:LiNbO3 (Ti:PPLN) channel waveguide Lambda = 16.6 microm) by using a temperature-gradient-control technique. With this technique, we have achieved a second-harmonic phase-matching bandwidth of more than 13 nm in a 74-mm-long Ti:PPLN waveguide, which has a 0.21-nm(More)
Laser-wakefield acceleration offers the promise of a compact electron accelerator for generating a multi-GeV electron beam using the huge field gradient induced by an intense laser pulse, compared to conventional rf accelerators. However, the energy and quality of the electron beam from the laser-wakefield accelerator have been limited by the power of the(More)
Particle acceleration using ultraintense, ultrashort laser pulses is one of the most attractive topics in relativistic laser-plasma research. We report proton and/or ion acceleration in the intensity range of 5×10(19) to 3.3×10(20) W/cm2 by irradiating linearly polarized, 30-fs laser pulses on 10-to 100-nm-thick polymer targets. The proton energy scaling(More)
The carrier-envelope phase (CEP) of femtosecond pulses from a mode-locked Ti:sapphire laser is stabilized using a novel method operating in the time domain. This is a direct and relatively simple method for stabilizing the CEP of femtosecond laser pulses, compared to the conventional method based on phase-locked loop. Using this method, we have directly(More)