Tae J. Lee

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The transcription factor Myc plays a central role in regulating cell-fate decisions, including proliferation, growth, and apoptosis. To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated. Recent studies suggest that such control of Myc can be achieved at the post-translational level via protein(More)
The transition of the mammalian cell from quiescence to proliferation is a highly variable process. Over the last four decades, two lines of apparently contradictory, phenomenological models have been proposed to account for such temporal variability. These include various forms of the transition probability (TP) model and the growth control (GC) model,(More)
Synthetic biology has emerged as a useful approach to decoding fundamental laws underlying biological control. Recent efforts have produced many exciting systems and generated substantial insights. These progresses highlight the potential of synthetic biology to impact diverse areas including biology, computation, engineering, and medicine. Biological(More)
Recent studies have shown that proximal arrangement of multiple genes can have complex effects on gene expression. For example, in the case of heterologous gene expression modules, certain arrangements of the selection marker and the gene expression cassette may have unintended consequences that limit the predictability and interpretability of module(More)
Pathogenic bacteria such as Listeria and Yersinia gain initial entry by binding to host target cells and stimulating their internalization. Bacterial uptake entails successive, increasingly strong associations between receptors on the surface of bacteria and hosts. Even with genetically identical cells grown in the same environment, there are vast(More)
Many cellular decision processes, including proliferation, differentiation, and phenotypic switching, are controlled by bistable signaling networks. In response to transient or intermediate input signals, these networks allocate a population fraction to each of two distinct states (e.g. OFF and ON). While extensive studies have been carried out to analyze(More)
Mathematical models are increasingly prevalent in systems biology with the goal of providing predictions and insight that may be less accessible by intuition alone. However, analysis of these models can be challenging because they are often defined by a large number of parameters and non-linear interactions between components. While brute-force numerical(More)
Gene regulation is typically described in terms of the recruitment of transcriptional machinery to genes in order to transcribe RNA from DNA. In this view, transcriptional rates depend on the availability of specific biomolecules called transcription factors, which help recruit and stabilize RNA polymerase, the enzyme responsible for transcription, to the(More)
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