Tadhg Nagle

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Previous studies have shown that the bradykinin agonist, RMP-7, can safely permeabilize the blood brain barrier (BBB) by activation of constitutive B2 receptors on endothelial cells. The paper describes a series of studies using quantitative autoradiography and intracarotid infusions of RMP-7 to further elucidate the effect on BBB permeability. Because(More)
The effect and mechanism of the blood-brain barrier-permeabilizing agent, RMP-7, was investigated in a series of studies employing a rat RG2 glioma model. Changes in uptake of carboplatin into brain tumor and various nontumor brain tissue regions was determined using a sophisticated image analysis system. This system permitted quantitative autoradiography(More)
This paper presents an insight into the emerging concept of Master Data Management (MDM) and highlights issues that both academics and business managers should consider to better understand the meaning of this 'hot topic'. This critical reflection paper is forward looking and attempts to make sense of the MDM concept and highlight the issues associated with(More)
Only recently, researchers and practitioners alike have begun to fully understand the potential of eLearning and have concentrated on new tools and technologies for creating, capturing and distributing knowledge. Focusing on the area of informal learning, this paper describes this emerging domain and assesses current semantic and Web 2.0 tools used in this(More)
Social network sites (SNS) are becoming increasingly important, both for individuals and organizations. These systems have affected social and cultural activities, work practices, and in particular the ways in which we discover, share and consume information goods. The functionality of SNS is emergent, shaped by user appropriation choices. In this paper,(More)
The debate on the usefulness of business models to the IT/IS and strategy domains is fraught with confusion and contradictory views. However, recent research has indicated a convergence of ideas and a solid role for the business model concept within industry and the research community. Based within the maturing e-Learning industry, this paper empirically(More)
There has been increasing attention in IS literature around the technology-business relationship and the concept of social alignment. However, little attention has been given to how or why social alignment should be developed. Further examining the concept this paper explores the development of social alignment within an innovation context. Using canonical(More)