Tadashi R. Kawashima

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We encountered an unusual case of hyperparathyroidism with both hemosiderin deposits on the ribs and low intensity on T2-weighted magnetic resonance imaging (MRI) caused by a parathyroid adenoma with multiple brown tumors that mimicked metastatic bone tumor due to false positive results on computed tomography (CT) and Tc-99m sestamibi (MIBI) imaging. The(More)
The incidence of the femoral neck fractures in 1985 was studied in Niigata Prefecture, Japan, which is on the “Japan Sea” at the central area of the Main Island of Japan. The author visited all hospitals within Niigata Prefecture, to study radiographs and records of patients who sustained femoral neck fractures. On October 1, 1985, the population of Niigata(More)
Saccharomyces cerevisiae has been used as a model system to investigate the mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage have been described in this organism. Using RNA-Seq analysis of nonsense-mediated mRNA decay (NMD) mutant strains, we show that many S. cerevisiae intron-containing genes exhibit usage of(More)
The incidence of the femoral neck fractures in 1989 was studied in Niigata Prefecture, which has a population of 2,481,441 (1,204,349 males and 12,277,092 females) as of January 1, 1989. The population over 65 years of age was 352,003, 12.5% of the total population (139,518 males and 212,485 females). The authors visited all hospitals in Niigata Prefecture(More)
The MATa1 gene encodes a transcriptional repressor that is an important modulator of sex-specific gene expression in Saccharomyces cerevisiae. MATa1 contains two small introns, both of which need to be accurately excised for proper expression of a functional MATa1 product and to avoid production of aberrant forms of the repressor. Here, we show that(More)
The role of many splicing factors in pre-mRNA splicing and the involvement of these factors in the processing of specific transcripts have often been defined through the analysis of loss-of-function mutants in vivo. Here we show that inactivating the nonsense-mediated mRNA decay (NMD) results in an enhancement of splicing phenotypes associated with several(More)
INTRODUCTION The aim of the present study was to investigate whether the concentration of arsenic (As) released from gray or white mineral trioxide aggregates (MTAs) met the requirement of the International Standards Organization (ISO) for dental cements. METHODS Sample preparations were carried out according to the ISO methods. After centrifugation of(More)
Coenzyme Qn (ubiquinone or Qn) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail of n isoprene units. Saccharomyces cerevisiae coq1-coq9 mutants have defects in Q biosynthesis, lack Q6, are respiratory defective, and sensitive to stress imposed by polyunsaturated fatty acids. The hallmark phenotype of the(More)
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