Tadashi Ogawa

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It has been empirically established that the cerebral cortical areas defined by Brodmann one hundred years ago solely on the basis of cellular organization are closely correlated to their function, such as sensation, association, and motion. Cytoarchitectonically distinct cortical areas have different densities and types of neurons. Thus, signaling patterns(More)
Natural scenes typically contain multiple objects that are unique in different stimulus dimensions so that an object with feature contrast to surrounding objects draws attention and pops out. Furthermore, if we have previous knowledge about the dimension in which a target object differs from the surrounding objects, we will attend to that dimension and more(More)
 The main purpose of the present study was to investigate adaptive properties in human smooth-pursuit eye movements generated by a peripheral moving target. In adaptation trials, a target appeared in the peripheral visual field and immediately moved away at a constant speed, and a subject made a saccade and postsaccadic pursuit responses to track it. The(More)
BACKGROUND & AIMS Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a dominant-negative mutant. METHODS Rats(More)
We have shown that a soluble receptor for vascular endothelial growth factor (sVEGFR), which adsorbs VEGF and may function as a dominant-negative receptor, suppresses tumor angiogenesis and enhances apoptosis of cancer cells, thereby inhibiting tumor growth [Cancer Res 60 (2000) 2169-2177]. In the present study, using as many as 11 cancer cell lines, we(More)
During a visual search, information about the visual attributes of an object and associated behavioral requirements is essential for discriminating a target object from others in the visual field. On the other hand, information about the object's position appears to be more important when orienting the eyes toward the target. To understand the neural(More)
Previous electrophysiological, neuroimaging and lesion studies have suggested that the anterior part of the monkey inferior temporal (IT) cortex, or area TE, plays an important role in colour processing. However, little is known about how colour information is distributed in these cortical regions. Here, we explored the distribution of colour-selective(More)
This paper reviews the role played by IgE-binding epitopes in eliciting clinical symptoms, the types of IgE-binding epitopes in allergenic proteins, the methods used to identify IgE-binding epitopes, and the availability of IgE-binding epitopes in allergenic sources. Finally, bioinformatics methods to assess protein allergenicity using knowledge of(More)
BACKGROUND AND OBJECTIVES In patients with acute cholecystitis who cannot undergo early laparoscopic cholecystectomy (within 72 hours), 6 weeks to 12 weeks after onset is widely considered the optimal timing for delayed laparoscopic cholecystectomy. However, there has been no clear consensus about it. We aimed to determine optimal timing for delayed(More)
Treatment of E. coli extract with iron/ascorbate preferentially inactivated NADP-isocitrate dehydrogenase without affecting glucose-6-phosphate dehydrogenase. NADP-Isocitrate dehydrogenase required divalent metals such as Mg2+, Mn2+ or Fe2+ ion. Iron/ascorbate-dependent inactivation of the enzyme was accompanied with the protein fragmentation as judged by(More)