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  • Satoru Eguchi, Kotaro Numaguchi, +9 authors Tadashi Inagami
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1998 (First Publication: 10 April 1998)
  • We have recently reported that angiotensin II (Ang II)-induced mitogen-activated protein kinase (MAPK) activation is mainly mediated by Ca2+-dependent activation of a protein tyrosine kinase throughContinue Reading
  • Satoru Eguchi, Peter J Dempsey, Gerald D. Frank, Evangeline D. Motley, Tadashi Inagami
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2001 (First Publication: 16 March 2001)
  • In cultured vascular smooth muscle cells (VSMC), the vasculotrophic factor, angiotensin II (AngII) activates three major MAPKs via the G(q)-coupled AT1 receptor. Extracellular signal-regulated kinaseContinue Reading
  • Atsuhiro Ichihara, Matsuhiko Hayashi, +11 authors Takao Saruta
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 2004 (First Publication: 15 October 2004)
  • We found that when a site-specific binding protein interacts with the "handle" region of the prorenin prosegment, the prorenin molecule undergoes a conformational change to its enzymatically activeContinue Reading
  • Yoshikazu Kambayashi, S. Bardhan, +4 authors Tadashi Inagami
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1993 (First Publication: 25 November 1993)
  • There are two major isoforms of the angiotensin II receptor, type 1 (AT1) and type 2 (AT2). AT2 is distinguished from AT1 with respect to its ligand selectivity, its insensitivity to non-hydrolyzableContinue Reading