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2,7,8-Trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), a metabolite of gamma-tocopherol and gamma-tocotrienol, was identified as a new endogenous natriuretic factor. However, gamma-tocopherol and gamma-tocotrienol, both precursors of gamma-CEHC, have never directly been observed to have natriuretic potency. Thus, we investigated whether(More)
Endogenous natriuretic factors are believed to be responsible for extracellular fluid homeostasis in mammals. A new endogenous natriuretic factor, Loma Linda University-alpha (LLU-alpha) has recently been proven to be a 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC), which is a metabolite of gamma-tocopherol (gamma-Toc). The purpose of(More)
We have previously reported that gamma-tocopherol (gamma-Toc) displays a natriuretic potency in rats fed a NaCl diet and administered 20 mg gamma-Toc. In this study, we investigated whether gamma-Toc has natriuretic potency at a dose lower or higher than 20 mg in rats given a NaCl diet. Male rats were fed a control diet or a NaCl diet and administered(More)
  • Sugaya K, Kadekawa K, Ashitomi K, T Ueda, Yamamoto H
  • 2012
Hypothesis / aims of study Micturition is primarily functions of the autonomic nervous system mediated by the spinobulbospinal reflex pathway passing through a coordination center located in the rostral brainstem, and this reflex pathway is modulated by the upper center in the cerebral cortex (cerebral micturition center). It has been reported that medial(More)
Synthetic α-tocopherol (α-Toc) contains equal amounts of eight different stereoisomers, and the four stereoisomers with the 2R configuration are generally more active than their correspoding 2S-isomers. We investigated the biodiscrimination of α-Toc stereoisomers during intestinal absorptionin situ andin vitro. Intestinal absorption of α-Toc stereoisomers(More)
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