Tada-atsu Imaizumi

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We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects. Gal-9(More)
The activity of platelet-activating factor acetylhydrolase, a specific metabolizing enzyme of platelet-activating factor (PAF), in plasma of 39 male subjects was determined radiochemically by the method of Stafforini et al., (1987) J Biol Chem 262: 4223–4230, to clarify to what extent PAF affects atherosclerotic disorders induced by habitual smoking. The(More)
To assess the role of platelet-activating factor (PAF) in smoking-induced vascular injury, the effect of cigarette smoking on PAF-like lipid (PAF-LL) in plasma was studied. The subjects were 12 young smokers (22±1.3 years old), 13 young non-smokers (22±2.1 years old), 14 older smokers (59±9.6 years old), and 11 older non-smokers (60±8.7 years old). Lipids(More)
A Clinical observation was carried out on primary infection type atypical mycobacteriosis (lung infection) in the Fuji City Central Hospital (Fuji-shi, Shizuokaken, Japan) during 1989-94. 1) Twenty-five out of 118 cases (21.8%) admitted to the tuberculosis ward of the hospital were atypical mycobacteriosis. Ten out of 25 cases with atypical mycobacteriosis(More)
Remnant like particle (RLP) is a lipoprotein produced by decomposition of chylomicron or very low density lipoprotein (VLDL). PLP was observed on serum of cases with active pulmonary tuberculosis. Serum level of RLP was decreased in all of the patients with pulmonary tuberculosis; below 2.5 mg/dl till 0 mg/dl. The level was gradually elevated with clinical(More)
It has been observed that lung tuberculosis shows a similar pathological feature with that of sarcoidosis. Serum angiotensin converting enzyme (ACE) was elevated in sarcoidosis. In the present study, serum ACE was measured in pulmonary tuberculosis patients. 1. ACE showed lower level in active tuberculosis. Elevation of serum ACE, however, was observed(More)
Hepatocyte growth factor (HGF) was observed in sera from cases with lung tuberculosis. 1. Serum HGF was elevated in cases with active lung tuberculosis. 2. Stabilization of the disease by treatment lowered the level of serum HGF. 3. General activation of mesenchymal system cells might be reflected in the elevation of serum HGF in active lung tuberculosis.
Immunosuppressive acid protein (IAP) was measured in 28 cases with active lung tuberculosis, 24 cases with old lung tuberculosis, and 20 controls. IAP elevated in active lung tuberculosis, but not in old lung tuberculosis and the control. Elevated IAP in active tuberculosis fell down gradually with the clinical improvement of the disease. IAP seems to be(More)
Lymphocyte surface marker from periferal blood of patients with active cavitary tuberculosis was observed. CD3+/HLA-DR + cell and CD25+/CD4 + cell were increased in cases with good clinical course. Disease course was prolonged in cases with no increase of such cells. CD4+/HLA-DR + cell was increased in cases with far advanced pulmonary lesions. Thus,(More)
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