Tabea Neumann

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Neurotrophins and their receptors play a key role in neurogenesis and survival. However, we and others have recently obtained evidence for a potential involvement of this receptor system in leukemia. To investigate mechanisms underlying the leukemogenic potential of activated neurotrophin receptor signaling, we analyzed in vivo leukemogenesis mediated by(More)
The transcription factor Evi1 has an outstanding role in the formation and transformation of hematopoietic cells. Its activation by chromosomal rearrangement induces a myelodysplastic syndrome with progression to acute myeloid leukemia of poor prognosis. Similarly, retroviral insertion-mediated upregulation confers a competitive advantage to transplanted(More)
In the present study 162 patients with clinically suspected diseases of the major salivary glands were examined via sonography (n = 162), sialography (n = 111) and CT-sialography (n = 49). The reliability of the three radiological procedures was assessed in diagnosing sialoadenitis, sialolithiasis and glandular and extraglandular tumors. Forty-seven(More)
Placental growth factor (PlGF), a VEGF-homolog implicated in tumor angiogenesis and adaptation to antiangiogenic therapy, is emerging as candidate target in malignancies. Here, we addressed the expression, function, and prognostic value of PlGF in neuroendocrine tumors (NETs). PlGF was determined in NET patients' sera collected retrospectively (n=88) and(More)
The systemic character of the rheumatoid arthritis and the collagenoses includes an extraarticular organ manifestation. Since the symptomatology of an organ participation is often covered over with dominating joint troubles its diagnostics is difficult. In 34 patients (22 with rheumatoid arthritis, 12 with collagenoses) with the help of non-invasive methods(More)
In 46 patients the common and internal carotid artery were examined by duplex sonography and intraarterial DSA in a prospective study. A correlation of 80% was found in diagnosis and degree of the pathological changes. Small lesions of the vessels are more exactly demonstrated by duplex sonography. In subtotal stenosis duplex sonography is inferior to(More)
Despite the multitude of the imaging procedures which are nowadays at our disposal the diagnostics of the carcinoma of the pancreas and particularly of the early carcinoma is now as ever difficult. On the basis of a multicentric team study about the diagnostic course in 62 patients with diagnosed carcinoma of the pancreas we conclude to an effective(More)