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Putranjivain A from Euphorbia jolkini inhibits both virus entry and late stage replication of herpes simplex virus type 2 in vitro.
Putranjivain A possesses antiviral activity, inhibiting viral attachment and penetration, and also interfering with the late stage of viral replication. Expand
Antioxidant and free radical scavenging activities of Terminalia chebula.
All tested extracts and pure compounds of T. chebula exhibited antioxidant activity at different magnitudes of potency, and the antioxidant activity of each pure compound was derived from different pathways and was suggested to be specific. Expand
The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines.
It is suggested that aloe-emodin may be useful in liver cancer prevention because it inhibited cell proliferation and induced apoptosis in both examined cell lines, but with different the antiproliferative mechanisms. Expand
Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread
It is suggested that the hydrolyzable tannins CHLA and PUG may be useful as competitors for glycosaminoglycans in the management of HSV-1 infections and that they may help reduce the risk for development of viral drug resistance during therapy with nucleoside analogues. Expand
Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn.
It is concluded that casuarinin possesses anti-herpesvirus activity in inhibiting viral attachment and penetration, and also disturbing the late event(s) of infection. Expand
Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles
The results suggested that excoecarianin merits to be further explored as an entry inhibitor against HSV-2 and could potentially be investigated for combinatorial drug treatment with nucleoside analogues such as ACV in therapeutic management of HSv-2 infection. Expand
Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro.
The acetone, ethanol and methanol extracts of P. urinaria were concluded to likely inhibit HSV-2 infection through disturbing the early stage of virus infection and through diminishing the virus infectivity. Expand
Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry
CHLA and PUG may be of value as broad-spectrum antivirals for limiting emerging/recurring viruses known to engage host cell GAGs for entry to suggest intriguing differences in the roles of GAG-interactions for these viruses. Expand
The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection.
Phyllanthus urinaria Linnea (Euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. Previously, the acetoneExpand
Determination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresis.
The HPLC and CE methods developed were both successfully applied to the assay of tannins in commercial samples of Chebulae Fructus and provided a better separation for most of the tannin examined. Expand