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OBJECTIVES/HYPOTHESIS We sought to investigate the role of desmoglein 3 in pathogenesis of sinonasal inverted papilloma (IP) and its malignant transformation. METHODS Fifteen subjects with sinonasal IP and 15 subjects of normal sphenoid sinus mucosa were enrolled. Each specimen was divided into two portions: one for mRNA expression analysis by real-time(More)
OBJECTIVE To evaluate hospitalization rates and duration of surgery associated with transnasal endoscopic marsupialization compared with sublabial excision in treating nasolabial cysts. DESIGN Retrospective clinical series. SETTING Large urban community hospital. PATIENTS Consecutive sample of 57 patients with nasolabial cysts treated from January 1,(More)
OBJECTIVES Isolated sphenoid sinus aspergilloma (ISSA) is a form of fungal sinus infection that is distinct from allergic fungal sinusitis, invasive fungal disease, and Aspergillus granulomas. In this study, we identify the characteristics of patients with ISSA to achieve timelier intervention for this easily neglected disease. METHODS In a retrospective(More)
This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with head and neck squamous cell carcinoma(More)
Nasal septal perforation presents a distinct challenge to otorhinolaryngologists, and is a problem for patients. Although it has a variety of causes, previous septal surgery is the most common reason. We present a 57-year-old woman who had recurrent chronic sinusitis. A left nasal mass was noted and excised via endoscopic sinus surgery. Invasive(More)
OBJECTIVES To evaluate the efficacy of the limited approach of functional endoscopic sinus surgery (FESS) in pediatric patients with chronic rhinosinusitis (CRS) and to interpret the indications for second-look endoscopy. DESIGN A retrospective review of medical records of patients who received pediatric FESS between January 1995 and September 2002 and a(More)
OBJECTIVES The goal of this article is to investigate the factors leading to protracted nasal discharge after pediatric endoscopic sinus surgery. METHODS A retrospective chart review of all pediatric patients who had received endoscopic sinus surgery for chronic rhinosinusitis between January 2002 and September 2006 was conducted. The patients were(More)
Overexpression of the DNA methyltransferase 3B (DNMT3B) gene and its effect on carcinogenesis has been demonstrated for various types of cancer. Recently, three single nucleotide polymorphisms (SNPs) of the DNMT3B promoter region, C46359T (-149C>T), -283T>C, and -579G>T have also been reported to be stratification markers that can predict an individual's(More)
Solitary abducens palsy secondary to isolated sphenoid sinus disease (ISSD) is rare and early management is important. There is no report regarding the results of endoscopic sinus surgery (ESS) for prolonged abducens palsy due to ISSD. We present four cases of ISSD with solitary abducens palsy that received ESS from 1995 through 2000. The interval between(More)
OBJECTIVES/HYPOTHESIS Many reports have advocated the feasibility of using an endoscope for the treatment of cerebrospinal fluid (CSF) rhinorrhea and skull base defect, and diversified endoscopic techniques and repairing materials have recently been proposed. This study determined the effectiveness of endoscopic repair of CSF leaks and interpreted the(More)