TN Seyfried

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Cancer cells express an abnormal metabolism characterized by increased glucose consumption owing to genetic mutations and mitochondrial dysfunction. Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively use ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tumor cells.(More)
GM1 gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid b-galactosidase (b-gal), resulting in accumulation of ganglioside GM1 and its asialo-form (GA1) primarily in the brain. In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (NB-DGJ), an imino sugar that inhibits ganglioside biosynthesis, in(More)
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