TK Hoffmann

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BACKGROUND Regulatory T cells (Treg) and dendritic cells (DC) play an important role in tumor immunity and immune escape. However, their interplay and the effects of anti-cancer therapy on the human immune system are largely unknown. METHODS For DC generation, CD14⊃+ monocytes were enriched by immunomagnetic selection from peripheral blood of advanced(More)
BACKGROUND Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS Ten human cell lines were obtained from HNSCC,(More)
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