TJM Smeets

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In normal and dwarfed Snell mice, the postnatal development through the first 70 days of life of the proximal tibial epiphysis and its growth plate has been studied, using histometric techniques and qualitative histological descriptions. The tibia appears to be fairly representative for longitudinal skeletal growth, since a linear relationship between(More)
The length of the tibia was studied in normal Snell mice (+/?) and in dwarfs (dw/dw) before and after treatment with human growth hormone (hGH) and thyroxine (T4) in relation with the histometrical development of the tibial proximal epiphysis. The aim of the study was to obtain more insight in the specific role of these hormones in the process of bone(More)
The effects of replacement therapy with growth hormone, somatomedins, prolactin, thyroxine and the combination of growth hormone and thyroxine on the proximal tibial epiphysis and its growth plate, have been studied in Snell dwarf mice by histometric measurements. All substances tested induce an increase of the partial tibia length, the width of the(More)
The separation of tylosin by micellar electrokinetic capillary chromatography with a mixed micelle system is described. Good selectivity was obtained with sodium phosphate buffer (80 mM, pH 7.5) containing 20 mM sodium cholate and 7 mM cetyltrimethylammonium bromide (CTAB). This method permits tylosin to be separated from its closely related substances(More)
In Snell dwarf mice, the influence of short-term treatment with human growth hormone (hGH) or thyroxine on the proliferative and sulphation activity of the proximal tibial growth plate was studied. By autoradiographic methods, the [3H]methylthymidine incorporation after a single injection was measured, after 2 hr incorporation time. The labelling index was(More)